Model-based approaches to predict drug-drug interactions associated with hepatic uptake transporters: preclinical, clinical and beyond.
about
Evaluation of Adverse Drug Properties with Cryopreserved Human Hepatocytes and the Integrated Discrete Multiple Organ Co-culture (IdMOC(TM)) SystemPhysiologically Based Pharmacokinetic (PBPK) Modeling and Simulation Approaches: A Systematic Review of Published Models, Applications, and Model VerificationRole of OATP-1B1 and/or OATP-1B3 in hepatic disposition of tyrosine kinase inhibitorsEffect of Ondansetron on Metformin Pharmacokinetics and Response in Healthy Subjects.Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell linesA mechanistic framework for in vitro-in vivo extrapolation of liver membrane transporters: prediction of drug-drug interaction between rosuvastatin and cyclosporineClinical impact of genetic variants of drug transporters in different ethnic groups within and across regions.Biomarkers and human hepatocytes.In vitro and in vivo approaches to characterize transporter-mediated disposition in drug discovery.Prediction of pharmacokinetics and drug-drug interactions when hepatic transporters are involved.Dealing with the complex drug-drug interactions: towards mechanistic models.Assessment of drug metabolism enzyme and transporter pharmacogenetics in drug discovery and early development: perspectives of the I-PWG.The Application of Physiologically Based Pharmacokinetic Modeling to Predict the Role of Drug Transporters: Scientific and Regulatory Perspectives.Predicting Clearance Mechanism in Drug Discovery: Extended Clearance Classification System (ECCS).Cellular Models and In Vitro Assays for the Screening of modulators of P-gp, MRP1 and BCRP.Mechanism-based pharmacokinetic modeling to evaluate transporter-enzyme interplay in drug interactions and pharmacogenetics of glyburide.Toward Prospective Prediction of Pharmacokinetics in OATP1B1 Genetic Variant Populations.Transporter-Enzyme Interplay: Deconvoluting Effects of Hepatic Transporters and Enzymes on Drug Disposition Using Static and Dynamic Mechanistic Models.Role of enterohepatic recirculation in drug disposition: cooperation and complications.Transporter-Mediated Hepatic Uptake Plays an Important Role in the Pharmacokinetics and Drug-Drug Interactions of Montelukast.Role of Hepatic Drug Transporters in Drug Development.
P2860
Q26801904-10E8665F-13AF-4CCE-84C1-8704B7EF4F4EQ28088352-E7787DBC-F05E-48FA-BCC8-165EC6386617Q28236180-665529BA-4172-4F93-9919-8F4ACA1B8D77Q36737021-3A2B5EF1-CEDF-4351-BE1A-52B69A9DE442Q37165815-804418A7-1CCB-4241-8602-CAC34C1F4402Q37470663-67D5D641-D9D5-4153-AF50-D56A78242802Q38160088-64CE0B0C-7FCB-426F-A3FC-D67C3CC36E3AQ38187449-2D736A0E-97FC-4442-AB0B-3C1064F5CAF0Q38214334-7E2C3DCC-F8A1-4D79-9D19-03095CB5F49CQ38233298-D5E447CD-1CAB-40AA-AC4A-3B3A1BBFD62BQ38302225-EB18A472-553A-4E6E-AC72-49D5AB1A6A17Q38798449-8ABFA264-26B4-4503-8C90-AB95235C7573Q38844656-175DF349-0760-49A8-8743-1132FEAACEC3Q38855314-243D617E-3896-43A8-8702-93EA82A69CDEQ39233839-4DFE190C-C86F-4047-831D-8CA5676BACDBQ41150870-A5D24B6D-5F5A-4F56-9281-1E9AACB000A1Q41706349-B996C126-C2EB-4FAF-B38A-0179514BBA42Q45243894-782BA998-17B3-4DF9-B3FF-4A8352D9DCA0Q46578287-1495A389-D89B-42FC-BC72-001A103025A9Q51485773-3C3D346B-FC37-4DA0-9F83-5106C88E1779Q51659233-8EE00E79-EF51-40C9-A53D-E18DE3628946
P2860
Model-based approaches to predict drug-drug interactions associated with hepatic uptake transporters: preclinical, clinical and beyond.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Model-based approaches to pred ...... clinical, clinical and beyond.
@en
type
label
Model-based approaches to pred ...... clinical, clinical and beyond.
@en
prefLabel
Model-based approaches to pred ...... clinical, clinical and beyond.
@en
P2093
P2860
P1476
Model-based approaches to pred ...... eclinical, clinical and beyond
@en
P2093
Ayman F El-Kattan
Hannah M Jones
Hugh A Barton
James R Gosset
Manthena V Varma
Theunis C Goosen
P2860
P304
P356
10.1517/17425255.2013.759210
P407
P50
P577
2013-01-21T00:00:00Z