G12/13-dependent signaling of G-protein-coupled receptors: disease context and impact on drug discovery.

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Gα12 overexpressed in hepatocellular carcinoma reduces microRNA-122 expression via HNF4α inactivation, which causes c-Met induction Regulation of RhoGEF proteins by G12/13-coupled receptors.Are GPCRs still a source of new targets?Gα12 regulates osteoclastogenesis by modulating NFATc1 expression.

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G12/13-dependent signaling of G-protein-coupled receptors: disease context and impact on drug discovery.

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G12/13-dependent signaling of ...... and impact on drug discovery.

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G12/13-dependent signaling of ...... and impact on drug discovery.

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G12/13-dependent signaling of ...... and impact on drug discovery.

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G12/13-dependent signaling of ...... and impact on drug discovery.

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Sandra Siehler

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A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho

Functional Selectivity and Classical Concepts of Quantitative Pharmacology

Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF

Physical and functional interactions of the lysophosphatidic acid receptors with PDZ domain-containing Rho guanine nucleotide exchange factors (RhoGEFs)

Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment

Rocks: multifunctional kinases in cell behaviour

Vascular system defects and impaired cell chemokinesis as a result of Galpha13 deficiency

Identification of a novel guanine nucleotide exchange factor for the Rho GTPase

Essential role for Galpha13 in endothelial cells during embryonic development

Characterization of G alpha 13-dependent plasma membrane recruitment of p115RhoGEF

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1591-1604

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scholarly article

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10.1517/17460441.2.12.1591

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English

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2007-12-01T00:00:00Z

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23488903

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G protein-coupled receptor

G12/13-dependent signaling of G-protein-coupled receptors: disease context and impact on drug discovery.

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P2860

P2860

G12/13-dependent signaling of G-protein-coupled receptors: disease context and impact on drug discovery.

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