Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies.
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Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body diseaseUpstream deregulation of calcium signaling in Parkinson's diseasePropagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.Additional rare variant analysis in Parkinson's disease cases with and without known pathogenic mutations: evidence for oligogenic inheritance.Role of alpha-synuclein in autophagy modulation of primary human T lymphocytesStat3 controls cell death during mammary gland involution by regulating uptake of milk fat globules and lysosomal membrane permeabilizationRegulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers.ATP6V0C knockdown in neuroblastoma cells alters autophagy-lysosome pathway function and metabolism of proteins that accumulate in neurodegenerative disease.The mitochondrial uncoupler DNP triggers brain cell mTOR signaling network reprogramming and CREB pathway up-regulationElevated GM3 plasma concentration in idiopathic Parkinson's disease: A lipidomic analysisPerturbation of neuronal cobalamin transport by lysosomal enzyme inhibitionQuality control gone wrong: mitochondria, lysosomal storage disorders and neurodegeneration.Gene therapy for the neurological manifestations in lysosomal storage disorders.Aberrant autophagy and parkinsonism: does correction rescue from disease progression?Autophagy in neuronal cells: general principles and physiological and pathological functions.Alterations in late endocytic trafficking related to the pathobiology of LRRK2-linked Parkinson's disease.Targeting the Autophagy/Lysosomal Degradation Pathway in Parkinson's Disease.Modulation of Neuroinflammation in the Central Nervous System: Role of Chemokines and Sphingolipids.LRRK2 and Autophagy.Prelysosomal Compartments in the Unconventional Secretion of Amyloidogenic Seeds.The emerging role of retromer in neuroprotection.The Coordinated Action of Calcineurin and Cathepsin D Protects Against α-Synuclein Toxicity.Progress toward an integrated understanding of Parkinson's disease.High Performance Liquid Chromatography-Mass Spectrometry (LC-MS) Based Quantitative Lipidomics Study of Ganglioside-NANA-3 Plasma to Establish Its Association with Parkinson's Disease Patients.Atp13a2 Deficiency Aggravates Astrocyte-Mediated Neuroinflammation via NLRP3 Inflammasome Activation.Parkinson's disease: From human genetics to clinical trials.Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression.
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P2860
Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies.
description
article científic
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article scientifique
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articol științific
@ro
articolo scientifico
@it
artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Dysfunction of the autophagy/l ...... the genetic synucleinopathies.
@en
type
label
Dysfunction of the autophagy/l ...... the genetic synucleinopathies.
@en
prefLabel
Dysfunction of the autophagy/l ...... the genetic synucleinopathies.
@en
P2860
P356
P1433
P1476
Dysfunction of the autophagy/l ...... the genetic synucleinopathies.
@en
P2093
Claudia Manzoni
P2860
P304
P356
10.1096/FJ.12-223842
P407
P577
2013-05-16T00:00:00Z