Minireview: The effects of species ortholog and SNP variation on receptors for free fatty acids. - Wikidata - wikimedia - TriplyDB

Minireview: The effects of species ortholog and SNP variation on receptors for free fatty acids.

Minireview: The effects of species ortholog and SNP variation on receptors for free fatty acids.

http://www.wikidata.org/entity/Q38107811

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Fatty Acid Regulation of Voltage- and Ligand-Gated Ion Channel Function A Single Amino Acid Mutation (R104P) in the E/DRY Motif of GPR40 Impairs Receptor Function Omega-3 fatty acids and other FFA4 agonists inhibit growth factor signaling in human prostate cancer cells.Expanding Duplication of Free Fatty Acid Receptor-2 (GPR43) Genes in the Chicken Genome.Human GPR42 is a transcribed multisite variant that exhibits copy number polymorphism and is functional when heterologously expressed.Drugs or diet?--Developing novel therapeutic strategies targeting the free fatty acid family of GPCRs Characterizing pharmacological ligands to study the long-chain fatty acid receptors GPR40/FFA1 and GPR120/FFA4.Polymorphic Variation in FFA Receptors: Functions and Consequences.Key Questions for Translation of FFA Receptors: From Pharmacology to Medicines.Positive and Negative Cross-Talk between Lysophosphatidic Acid Receptor 1, Free Fatty Acid Receptor 4, and Epidermal Growth Factor Receptor in Human Prostate Cancer Cells.The acute glucose lowering effect of specific GPR120 activation in mice is mainly driven by glucagon-like peptide 1.Pharmacological Tool Compounds for the Free Fatty Acid Receptor 4 (FFA4/GPR120).

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Minireview: The effects of species ortholog and SNP variation on receptors for free fatty acids.

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Molecular Endocrinology

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Minireview: The effects of spe ...... receptors for free fatty acids

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Graeme Milligan

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Hannah Murdoch

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Creative Commons Attribution-NonCommercial

P2860

Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41

Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids

Sequence polymorphisms provide a common consensus sequence for GPR41 and GPR42

A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1

The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids

Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor

A map of human genome variation from population-scale sequencing

GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects

Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.

GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo.

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1177-1187

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10.1210/ME.2013-1085

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8

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2013-05-17T00:00:00Z

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cell surface receptor

membrane proteins

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