The mechanisms of Hedgehog signalling and its roles in development and disease.
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Extracellular Matrix Regulation of Stem Cell BehaviorMicroRNAs in liver fibrosis: Focusing on the interaction with hedgehog signalingRole of Hedgehog Signaling Pathway in NASHThe emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancerHedgehog signaling: modulation of cancer properies and tumor mircroenvironmentEchoes of the embryo: using the developmental biology toolkit to study cancerMorphogen rules: design principles of gradient-mediated embryo patterningHedgehog Cholesterolysis: Specialized Gatekeeper to Oncogenic SignalingThe Hedgehog Signalling Pathway in Cell Migration and Guidance: What We Have Learned from Drosophila melanogasterIns and outs of GPCR signaling in primary ciliaHedgehog Signaling in the Maintenance of Cancer Stem CellsRoles for Hedgehog signaling in adult organ homeostasis and repairAutophagy and regulation of cilia function and assemblyCooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapyCiliary subcompartments: how are they established and what are their functions?Molecular mechanisms of epithelial-mesenchymal transitionCompartments within a compartment: what C. elegans can tell us about ciliary subdomain composition, biogenesis, function, and diseaseContext-dependent signal integration by the GLI code: the oncogenic load, pathways, modifiers and implications for cancer therapyOligomerization and endocytosis of Hedgehog is necessary for its efficient exovesicular secretionSingle-molecule imaging of Hedgehog pathway protein Smoothened in primary cilia reveals binding events regulated by Patched1Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation.Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signalingUndercover: gene control by metabolites and metabolic enzymesSonidegib, a novel smoothened inhibitor for the treatment of advanced basal cell carcinomaMolecular pathways: novel approaches for improved therapeutic targeting of Hedgehog signaling in cancer stem cellsThe Hedgehog signalling pathway in bone formationYAP and TAZ: a nexus for Hippo signaling and beyondCyclopamine tartrate, an inhibitor of Hedgehog signaling, strongly interferes with mitochondrial function and suppresses aerobic respiration in lung cancer cellsHedgehog Proteins Consume Steroidal CYP17A1 Antagonists: Potential Therapeutic Significance in Advanced Prostate CancerStructural basis of Smoothened regulation by its extracellular domainsA hypomorphic allele reveals an important role of inturned in mouse skeletal developmentA Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia ElongationGata6-Dependent GLI3 Repressor Function is Essential in Anterior Limb Progenitor Cells for Proper Limb DevelopmentA mutation in the mouse ttc26 gene leads to impaired hedgehog signalingMutations in human homologue of chicken talpid3 gene (KIAA0586) cause a hybrid ciliopathy with overlapping features of Jeune and Joubert syndromesDevelopmental origins of NAFLD: a womb with a clue.The role of canonical and non-canonical Hedgehog signaling in tumor progression in a mouse model of small cell lung cancer.Genetic and Molecular Analyses indicate independent effects of TGIFs on Nodal and Gli3 in neural tube patterning.Cilia-mediated Hedgehog signaling controls form and function in the mammalian larynx.A ligand-directed divergent catalytic approach to establish structural and functional scaffold diversity.
P2860
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P2860
The mechanisms of Hedgehog signalling and its roles in development and disease.
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article científic
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article scientifique
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articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
The mechanisms of Hedgehog signalling and its roles in development and disease.
@en
type
label
The mechanisms of Hedgehog signalling and its roles in development and disease.
@en
prefLabel
The mechanisms of Hedgehog signalling and its roles in development and disease.
@en
P356
P1476
The mechanisms of Hedgehog signalling and its roles in development and disease.
@en
P2093
Pascal P Thérond
P2888
P304
P356
10.1038/NRM3598
P577
2013-05-30T00:00:00Z
P6179
1013834546