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Prostaglandin E Receptor Subtype 4 Signaling in the Heart: Role in Ischemia/Reperfusion Injury and Cardiac HypertrophyEpigenetic activation of the prostaglandin receptor EP4 promotes resistance to endocrine therapy for breast cancerCOX-1/PGE2/EP4 alleviates mucosal injury by upregulating β-arr1-mediated Akt signaling in colitis.Regulation of pancreatic β-cell function and mass dynamics by prostaglandin signaling.EP4 inhibition attenuates the development of diabetic and non-diabetic experimental kidney disease.[EXPRESS] Epac and Nociceptor Sensitization.Sequence analysis and identification of new isoform of EP4 receptors in different atlantic salmon tissues (Salmo salar L.) and its role in PGE2 induced immunomodulation in vitro.Prostaglandin E2 Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human Macrophages.Novel link between prostaglandin E2 (PGE2) and cholinergic signaling in lung cancer: The role of c-Jun in PGE2-induced α7 nicotinic acetylcholine receptor expression and tumor cell proliferationMolecular Characterization of E-Type Prostanoid Receptor 4 (EP4) from Ayu (Plecoglossus altivelis) and Its Functional Analysis in the Monocytes/Macrophages.Activation of EP4 receptors prevents endotoxin-induced neutrophil infiltration into the airways and enhances microvascular barrier function.Myeloid Cell Prostaglandin E2 Receptor EP4 Modulates Cytokine Production but Not Atherogenesis in a Mouse Model of Type 1 Diabetes.Molecular inhibition of prostaglandin E2 with GW627368X: Therapeutic potential and preclinical safety assessment in mouse sarcoma model.Inactivation of PI3-K/Akt and reduction of SP1 and p65 expression increase the effect of solamargine on suppressing EP4 expression in human lung cancer cellsProstaglandin E2 inhibits Tr1 cell differentiation through suppression of c-MafGW627368X inhibits proliferation and induces apoptosis in cervical cancer by interfering with EP4/EGFR interactive signalingLong-term exposure to PGE2 causes homologous desensitization of receptor-mediated activation of protein kinase A.Heterotrimeric G protein signaling in polycystic kidney diseaseTargeting EP4 downstream c-Jun through ERK1/2-mediated reduction of DNMT1 reveals novel mechanism of solamargine-inhibited growth of lung cancer cellsChronic kidney disease: targeting prostaglandin E2 receptors.Exogenous arachidonic acid mediates permeability of human brain microvessel endothelial cells through prostaglandin E2 activation of EP3 and EP4 receptors.LY3127760, a Selective Prostaglandin E4 (EP4) Receptor Antagonist, and Celecoxib: A Comparison of Pharmacological Profiles.Molecular mechanisms of target recognition by lipid GPCRs: relevance for cancer.Direct growth-inhibitory effects of prostaglandin E2 in pancreatic cancer cells in vitro through an EP4/PKA-mediated mechanism.EP4 receptor promotes invadopodia and invasion in human breast cancer.Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice.Endogenous prostaglandin E2 amplifies IL-33 production by macrophages through an E prostanoid (EP)2/EP4-cAMP-EPAC-dependent pathway.Convergence of Sex Differences and the Neuroimmune System in Autism Spectrum Disorder.Pathology and molecular mechanisms of coarctation of the aorta and its association with the ductus arteriosus.Stimulating TRPV1 externalization and synthesis in dorsal root ganglion neurons contributes to PGE2 potentiation of TRPV1 activity and nociceptor sensitization.Characterization of Eicosanoids Produced by Adipocyte Lipolysis: IMPLICATION OF CYCLOOXYGENASE-2 IN ADIPOSE INFLAMMATIONProstaglandin E2 facilitates subcellular translocation of the EP4 receptor in neuroectodermal NE-4C stem cells.Cellular density-dependent down-regulation of EP4 prostanoid receptors via the up-regulation of hypoxia-inducible factor-1α in HCA-7 human colon cancer cells.Cigarette smoke activates CFTR through ROS-stimulated cAMP signaling in human bronchial epithelial cells.Prostaglandin E receptor-4 receptor mediates endothelial barrier-enhancing and anti-inflammatory effects of oxidized phospholipids.Tissue-type plasminogen activator contributes to remodeling of the rat ductus arteriosus.Signalling transduction events involved in agonist-induced PGE2/EP4 receptor externalization in cultured rat dorsal root ganglion neurons.PGE1 and E3 show lower efficacies than E2 to β-catenin-mediated activity as biased ligands of EP4 prostanoid receptors.Expression of prostaglandin E2 and EP receptors in human papillary thyroid carcinoma.Prostaglandin E2 Inhibition of IL-27 Production in Murine Dendritic Cells: A Novel Mechanism That Involves IRF1.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
The prostanoid EP4 receptor and its signaling pathway.
@en
type
label
The prostanoid EP4 receptor and its signaling pathway.
@en
prefLabel
The prostanoid EP4 receptor and its signaling pathway.
@en
P2093
P356
P1476
The prostanoid EP4 receptor and its signaling pathway
@en
P2093
Kousaku Iwatsubo
Takayuki Fujita
Utako Yokoyama
Yoshihiro Ishikawa
P304
P356
10.1124/PR.112.007195
P577
2013-06-17T00:00:00Z