Sperm PLCζ: from structure to Ca2+ oscillations, egg activation and therapeutic potential.
about
The Novel Functions of the PLC/PKC/PKD Signaling Axis in G Protein-Coupled Receptor-Mediated Chemotaxis of NeutrophilsPLCζ or PAWP: revisiting the putative mammalian sperm factor that triggers egg activation and embryogenesisHomozygous mutation of PLCZ1 leads to defective human oocyte activation and infertility that is not rescued by the WW-binding protein PAWPSperm-specific post-acrosomal WW-domain binding protein (PAWP) does not cause Ca2+ release in mouse oocytes.Phosphoinositide-specific phospholipase C in health and disease.Rescue of failed oocyte activation after ICSI in a mouse model of male factor infertility by recombinant phospholipase CζFourteen babies born after round spermatid injection into human oocytesSignal transduction in mammalian oocytes during fertilization.Essential Role of the EF-hand Domain in Targeting Sperm Phospholipase Cζ to Membrane Phosphatidylinositol 4,5-Bisphosphate (PIP2).Regulation of ribosomal RNA expression across the lifespan is fine-tuned by maternal diet before implantation.Novel signalling mechanism and clinical applications of sperm-specific PLCζ.Oocyte activation deficiency: a role for an oocyte contribution?Egg Activation at Fertilization.Viable offspring after imaging of Ca2+ oscillations and visualization of the cortical reaction in mouse eggs.PLCζ is the physiological trigger of the Ca2+ oscillations that induce embryogenesis in mammals but conception can occur in its absence.Functional disparity between human PAWP and PLCζ in the generation of Ca2+ oscillations for oocyte activation.Dissipative structures and biological rhythms.New Insights into the Molecular Events of Mammalian Fertilization
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P2860
Sperm PLCζ: from structure to Ca2+ oscillations, egg activation and therapeutic potential.
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article científic
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article scientifique
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articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Sperm PLCζ: from structure to ...... ion and therapeutic potential.
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type
label
Sperm PLCζ: from structure to ...... ion and therapeutic potential.
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prefLabel
Sperm PLCζ: from structure to ...... ion and therapeutic potential.
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P2860
P1433
P1476
Sperm PLCζ: from structure to Ca2+ oscillations, egg activation and therapeutic potential
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P2093
Junaid Kashir
Karl Swann
P2860
P304
P356
10.1016/J.FEBSLET.2013.10.008
P407
P577
2013-10-21T00:00:00Z