Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study.
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Triclosan in water, implications for human and environmental healthA critical review of perfluorooctanoate and perfluorooctanesulfonate exposure and immunological health conditions in humansPrenatal exposure to di-(2-ethylhexyl) phthalate (DEHP) affects reproductive outcomes in female miceIdentification of modulators of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) in a mouse liver gene expression compendiumChemical and Hormonal Effects on STAT5b-Dependent Sexual Dimorphism of the Liver TranscriptomeThe impact of PPARα activation on whole genome gene expression in human precision cut liver slicesPPARα via HNF4α regulates the expression of genes encoding hepatic amino acid catabolizing enzymes to maintain metabolic homeostasis.Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendiumThe Contribution of Peroxisome Proliferator-Activated Receptor Alpha to the Relationship Between Toxicokinetics and Toxicodynamics of Trichloroethylene.Induction of endogenous retroelements as a potential mechanism for mouse-specific drug-induced carcinogenicity.Does GLP enhance the quality of toxicological evidence for regulatory decisions?First Trimester Phthalate Exposure and Infant Birth Weight in the Infant Development and Environment Study.Dexamethasone Pretreatment Alleviates Isoniazid/Lipopolysaccharide Hepatotoxicity: Inhibition of Inflammatory and Oxidative Stress.A critical review of perfluorooctanoate and perfluorooctanesulfonate exposure and cancer risk in humans.Mode of action analysis for pesticide-induced rodent liver tumours involving activation of the constitutive androstane receptor: relevance to human cancer risk.The use of mode of action information in risk assessment: quantitative key events/dose-response framework for modeling the dose-response for key events.A critical assessment of the methodologies to investigate the role of inhibition of apoptosis in rodent hepatocarcinogenesis.Contribution of new technologies to characterization and prediction of adverse effects.Editor's Highlight: Dose-Response Analysis of RNA-Seq Profiles in Archival Formalin-Fixed Paraffin-Embedded Samples.Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups.Applying the erythrocyte Pig-a assay concept to rat epididymal sperm for germ cell mutagenicity evaluation.Perfluoroalkyl acids-induced liver steatosis: Effects on genes controlling lipid homeostasis.A comprehensive review of regulatory test methods for endocrine adverse health effects.PPARα-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling.Nuclear receptors and nonalcoholic fatty liver disease.Mode of action analysis for rat hepatocellular tumors produced by the synthetic pyrethroid momfluorothrin: evidence for activation of the constitutive androstane receptor (CAR) and mitogenicity in rat hepatocytes.Dose-response analysis of epigenetic, metabolic, and apical endpoints after short-term exposure to experimental hepatotoxicants.An Evaluation of the Human Relevance of the Lung Tumors Observed in Female Mice Treated With Permethrin Based on Mode of Action.Origin of the TTC values for compounds that are genotoxic and/or carcinogenic and an approach for their re-evaluation.Pathway Based Toxicology and Fit-for-Purpose Assays.Exposure to perfluoroundecanoic acid (PFUnDA) accelerates insulitis development in a mouse model of type 1 diabetes.The role of hepatocyte nuclear factor 4-alpha in perfluorooctanoic acid- and perfluorooctanesulfonic acid-induced hepatocellular dysfunction.Involvement of Mouse Constitutive Androstane Receptor in Acifluorfen-Induced Liver Injury and Subsequent Tumor Development.Dose and Effect Thresholds for Early Key Events in a PPARα-Mediated Mode of Action.Mechanistic Investigation of Toxaphene Induced Mouse Liver Tumors.Comparative time course profiles of phthalate stereoisomers in mice.Characterization of inter-tissue and inter-strain variability of TCE glutathione conjugation metabolites DCVG, DCVC, and NAcDCVC in the mouse.Toxaphene-induced mouse liver tumorigenesis is mediated by the constitutive androstane receptor.In vivo genotoxicity of Ginkgo biloba extract in gpt delta mice and constitutive androstane receptor knockout mice.Changes in gene expression following long-term in vitro exposure of Macaca mulatta trophoblast stem cells to biologically relevant levels of endocrine disruptors.
P2860
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P2860
Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
2013年學術文章
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2013年學術文章
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name
Mode of action framework analy ...... alpha (PPARα) as a case study.
@en
type
label
Mode of action framework analy ...... alpha (PPARα) as a case study.
@en
prefLabel
Mode of action framework analy ...... alpha (PPARα) as a case study.
@en
P2093
P2860
P1476
Mode of action framework analy ...... alpha (PPARα) as a case study
@en
P2093
B Timothy Hummer
Bette Meek
Christopher Lau
J Christopher Corton
James A Popp
James E Klaunig
Jennifer Seed
Lorenz Rhomberg
Michael L Cunningham
P2860
P356
10.3109/10408444.2013.835784
P407
P50
P577
2013-11-04T00:00:00Z