Chimeric rodents with humanized liver: bridging the preclinical/clinical trial gap in ADME/toxicity studies.

Chimeric rodents with humanized liver: bridging the preclinical/clinical trial gap in ADME/toxicity studies.

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http://www.wikidata.org/entity/Q38169790
Discovery and resupply of pharmacologically active plant-derived natural products: A reviewA novel mouse model for stable engraftment of a human immune system and human hepatocytesAssessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound.Comparative Medicine in the Twenty-First Century: Where are We Now and Where Do We Go from Here?Novel pre-clinical methodologies for pharmacokinetic drug-drug interaction studies: spotlight on "humanized" animal models.Towards an HBV cure: state-of-the-art and unresolved questions--report of the ANRS workshop on HBV cure.Hepatotoxic effects of cyproconazole and prochloraz in wild-type and hCAR/hPXR mice.Functional Integrity of the Chimeric (Humanized) Mouse Liver: Enzyme Zonation, Physiologic Spaces, and Hepatic Enzymes and Transporters.Human hepatocytes support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogen sodium phenobarbital in an in vivo study using a chimeric mouse with humanized liver.Simulation of human plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling.Human relevance of rodent liver tumour formation by constitutive androstane receptor (CAR) activators
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Chimeric rodents with humanized liver: bridging the preclinical/clinical trial gap in ADME/toxicity studies.

Item
http://www.wikidata.org/entity/Q38169790
description
article científic
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article scientifique
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articol științific
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articolo scientifico
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artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artículo científico
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Chimeric rodents with humanize ...... gap in ADME/toxicity studies.
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type
label
Chimeric rodents with humanize ...... gap in ADME/toxicity studies.
@en
prefLabel
Chimeric rodents with humanize ...... gap in ADME/toxicity studies.
@en
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Chimeric rodents with humanize ...... gap in ADME/toxicity studies.
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P2093
P2860
P304
P31
P356
10.3109/00498254.2013.867553
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P433
P478
P577
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