Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases?
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Current and potential treatments for ubiquitous but neglected herpesvirus infectionsHerpesviral G protein-coupled receptors activate NFAT to induce tumor formation via inhibiting the SERCA calcium ATPaseCytomegalovirus Restructures Lipid Rafts via a US28/CDC42-Mediated Pathway, Enhancing Cholesterol Efflux from Host Cells.Structural Analysis of Chemokine Receptor-Ligand Interactions.Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors.Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor.Hunting for the function of orphan GPCRs - beyond the search for the endogenous ligand.The Cytoplasmic C-Tail of the Mouse Cytomegalovirus 7 Transmembrane Receptor Homologue, M78, Regulates Endocytosis of the Receptor and Modulates Virus Replication in Different Cell Types.Mutations in the C-terminal region affect subcellular localization of crucian carp herpesvirus (CaHV) GPCR.US28, a Virally-Encoded GPCR as an Antiviral Target for Human Cytomegalovirus Infection.Targeting the latent cytomegalovirus reservoir with an antiviral fusion toxin protein.Viral manipulation of the host immune response.The future of antiviral immunotoxins.The HCMV US28 vGPCR induces potent Gαq/PLC-β signaling in monocytes leading to increased adhesion to endothelial cells.Hijacking GPCRs by viral pathogens and tumor.Mechanisms of Regulation of the Chemokine-Receptor Network.BZLF1 Attenuates Transmission of Inflammatory Paracrine Senescence in Epstein-Barr Virus-Infected Cells by Downregulating Tumor Necrosis Factor Alpha.Human cytomegalovirus encoded chemokine receptor US28 activates the HIF-1α/PKM2 axis in glioblastoma cells.The Viral G Protein-Coupled Receptor ORF74 Hijacks β-Arrestins for Endocytic Trafficking in Response to Human Chemokines.Chemokines encoded by herpesviruses.Novel Chemokine-Based Immunotoxins for Potent and Selective Targeting of Cytomegalovirus Infected Cells.Attenuation of chemokine receptor function and surface expression as an immunomodulatory strategy employed by human cytomegalovirus is linked to vGPCR US28.Structural biology. Viral chemokine mimicry.Latency-Associated Expression of Human Cytomegalovirus US28 Attenuates Cell Signaling Pathways To Maintain Latent Infection.GPCR Retreat 2014: a good view leads to many discoveries!CADM1 is essential for KSHV-encoded vGPCR-and vFLIP-mediated chronic NF-κB activation.The constitutive activity of the virally encoded chemokine receptor US28 accelerates glioblastoma growth.The Immunomodulatory Capacity of an Epstein-Barr Virus Abortive Lytic Cycle: Potential Contribution to Viral Tumorigenesis.CXCR7 Targeting and Its Major Disease Relevance.US28: HCMV's Swiss Army Knife
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Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases?
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article científic
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article scientifique
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articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases?
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type
label
Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases?
@en
prefLabel
Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases?
@en
P2093
P2860
P356
P1476
Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases?
@en
P2093
Henry F Vischer
Marco Siderius
Martine J Smit
P2860
P2888
P304
P356
10.1038/NRD4189
P577
2014-01-21T00:00:00Z