Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis.
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Perturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human diseaseStructure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activationThe Crystal Structure of the Ubiquitin-like Domain of Ribosome Assembly Factor Ytm1 and Characterization of Its Interaction with the AAA-ATPase MidasinInhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signalingThe cell proliferation antigen Ki-67 organises heterochromatinRibosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesisRibosomal proteins and human diseases: pathogenesis, molecular mechanisms, and therapeutic implicationsRibosomopathies and the paradox of cellular hypo- to hyperproliferation.Small molecule BMH-compounds that inhibit RNA polymerase I and cause nucleolar stress.Reduced expression of the mouse ribosomal protein Rpl17 alters the diversity of mature ribosomes by enhancing production of shortened 5.8S rRNA.Depletion of the cisplatin targeted HMGB-box factor UBF selectively induces p53-independent apoptotic death in transformed cells.Phosphoproteomics Analysis of Endometrium in Women with or without Endometriosis.Functions of ribosomal proteins in assembly of eukaryotic ribosomes in vivo.Human AATF/Che-1 forms a nucleolar protein complex with NGDN and NOL10 required for 40S ribosomal subunit synthesis.The human box C/D snoRNAs U3 and U8 are required for pre-rRNA processing and tumorigenesis.Emerging roles of p53 and other tumour-suppressor genes in immune regulationp53 and ribosome biogenesis stress: the essentials.Elucidation of the genetic and epigenetic landscape alterations in RNA binding proteins in glioblastoma.GRWD1 negatively regulates p53 via the RPL11-MDM2 pathway and promotes tumorigenesis.Human rpL3 plays a crucial role in cell response to nucleolar stress induced by 5-FU and L-OHP.Physical and functional interaction of the TPL2 kinase with nucleophosmin.Therapeutic dosages of aspirin counteract the IL-6 induced pro-tumorigenic effects by slowing down the ribosome biogenesis rate.PIM1 destabilization activates a p53-dependent response to ribosomal stress in cancer cellsDepletion of ribosomal protein S19 causes a reduction of rRNA synthesis.Inhibition of post-transcriptional steps in ribosome biogenesis confers cytoprotection against chemotherapeutic agents in a p53-dependent manner.The pre-existing population of 5S rRNA effects p53 stabilization during ribosome biogenesis inhibitionRibosomal protein L4 is a novel regulator of the MDM2-p53 loop.TPL2-NPM-p53 pathway monitors nucleolar stress.The G-patch protein NF-κB-repressing factor mediates the recruitment of the exonuclease XRN2 and activation of the RNA helicase DHX15 in human ribosome biogenesis.A novel mouse model provides insights into the neutropenia associated with the ribosomopathy Shwachman-Diamond syndrome.The nuclear mitotic apparatus protein NuMA controls rDNA transcription and mediates the nucleolar stress response in a p53-independent manner.Tuning the ribosome: The influence of rRNA modification on eukaryotic ribosome biogenesis and function.Ribosome biogenesis in cancer: new players and therapeutic avenues.Perturbation of RNA Polymerase I transcription machinery by ablation of HEATR1 triggers the RPL5/RPL11-MDM2-p53 ribosome biogenesis stress checkpoint pathway in human cells.How Ribosomes Translate Cancer.GRWD1, a new player among oncogenesis-related ribosomal/nucleolar proteins.Inactivation of ribosomal protein S27-like confers radiosensitivity via the Mdm2-p53 and Mdm2-MRN-ATM axes.Two Nucleolar Proteins, GDP1 and OLI2, Function As Ribosome Biogenesis Factors and Are Preferentially Involved in Promotion of Leaf Cell Proliferation without Strongly Affecting Leaf Adaxial-Abaxial Patterning in Arabidopsis thaliana.New insights into HEATR1 functions.Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis.
P2860
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P2860
Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis.
description
article científic
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article scientifique
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articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis.
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type
label
Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis.
@en
prefLabel
Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis.
@en
P1476
Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis
@en
P2093
Giulio Donati
Maja Cokaric Brdovcak
P304
P356
10.1016/J.BBADIS.2013.08.014
P407
P577
2013-10-26T00:00:00Z