Toward predictive models for drug-induced liver injury in humans: are we there yet?
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Drug-induced liver injury: Towards early prediction and risk stratificationA New Structure-Activity Relationship (SAR) Model for Predicting Drug-Induced Liver Injury, Based on Statistical and Expert-Based Structural AlertsZeGlobalTox: An Innovative Approach to Address Organ Drug Toxicity Using Zebrafish.Safety evaluation of chinese medicine injections with a cell imaging-based multiparametric assay revealed a critical involvement of mitochondrial function in hepatotoxicity.Prediction of Drug-Induced Liver Injury in Micropatterned Co-cultures Containing iPSC-Derived Human Hepatocytes.A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicityComparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication.Idiosyncratic Drug-Induced Liver Injury (IDILI): Potential Mechanisms and Predictive Assays.Development of novel tools for the in vitro investigation of drug-induced liver injury.Development and regulatory application of microRNA biomarkers.Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs.In silico Prediction of Drug-induced Liver Injury Based on Adverse Drug Reaction Reports.Current limitations and future opportunities for prediction of DILI from in vitro.3D Cultivation Techniques for Primary Human Hepatocytes.Unraveling cellular pathways contributing to drug-induced liver injury by dynamical modeling.Test systems in drug discovery for hazard identification and risk assessment of human drug-induced liver injury.QSAR Models at the US FDA/NCTR.Setting Clinical Exposure Levels of Concern for Drug-Induced Liver Injury (DILI) Using Mechanistic in vitro Assays.Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury.Predicting Drug-Induced Cholestasis with the Help of Hepatic Transporters-An in Silico Modeling Approach.A testing strategy to predict risk for drug-induced liver injury in humans using high-content screen assays and the 'rule-of-two' model.Development of Decision Forest Models for Prediction of Drug-Induced Liver Injury in Humans Using A Large Set of FDA-approved Drugs.Integration of metabolomics and transcriptomics in nanotoxicity studies.A Model to predict severity of drug-induced liver injury in humans.In Vitro Drug-Induced Liver Injury Prediction: Criteria Optimization of Efflux Transporter IC50 and Physicochemical Properties.Metabolomics of Hydrazine-Induced Hepatotoxicity in Rats for Discovering Potential Biomarkers.A multi-center preclinical study of gadoxetate DCE-MRI in rats as a biomarker of drug induced inhibition of liver transporter function.Models of Drug Induced Liver Injury (DILI) - Current Issues and Future Perspectives
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Toward predictive models for drug-induced liver injury in humans: are we there yet?
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article científic
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articolo scientifico
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artigo científico
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Toward predictive models for drug-induced liver injury in humans: are we there yet?
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type
label
Toward predictive models for drug-induced liver injury in humans: are we there yet?
@en
prefLabel
Toward predictive models for drug-induced liver injury in humans: are we there yet?
@en
P2093
P2860
P356
P1476
Toward predictive models for drug-induced liver injury in humans: are we there yet?
@en
P2093
Halil Bisgin
Huixiao Hong
Jürgen Borlak
Lillian Tong
Minjun Chen
P2860
P304
P356
10.2217/BMM.13.146
P50
P577
2014-01-01T00:00:00Z