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Successful therapies for Alzheimer's disease: why so many in animal models and none in humans?Potentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression.Innate Immunity Fights Alzheimer's DiseaseAPOE-modulated Aβ-induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspectiveCerebrospinal fluid analysis detects cerebral amyloid-β accumulation earlier than positron emission tomographyThe Alzheimer disease protective mutation A2T modulates kinetic and thermodynamic properties of amyloid-β (Aβ) aggregation.Molecular basis for mid-region amyloid-β capture by leading Alzheimer's disease immunotherapies.The Na+/H+ exchanger NHE6 modulates endosomal pH to control processing of amyloid precursor protein in a cell culture model of Alzheimer disease.Increased susceptibility to oxidative death of lymphocytes from Alzheimer patients correlates with dementia severity.Long-term treatment with active Aβ immunotherapy with CAD106 in mild Alzheimer's diseaseStructure-Based Peptide Design to Modulate Amyloid Beta Aggregation and Reduce CytotoxicitySmall molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance.APP overexpression in the absence of NPC1 exacerbates metabolism of amyloidogenic proteins of Alzheimer's disease.Excess of rare coding variants in PLD3 in late- but not early-onset Alzheimer's disease.ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology.The Enemy within: Innate Surveillance-Mediated Cell Death, the Common Mechanism of Neurodegenerative Disease.Pittsburgh compound B imaging and cerebrospinal fluid amyloid-β in a multicentre European memory clinic study.Original Research: Influence of okadaic acid on hyperphosphorylation of tau and nicotinic acetylcholine receptors in primary neuronsSoluble Amyloid-beta Aggregates from Human Alzheimer's Disease Brains.Adiponectin Regulates the Polarization and Function of Microglia via PPAR-γ Signaling Under Amyloid β Toxicity.β-Amyloid peptides and amyloid plaques in Alzheimer's disease.The Role of TREM2 in Alzheimer's Disease and Other Neurological Disorders.Masitinib for the treatment of mild to moderate Alzheimer's disease.Impact of physiological, pathological and environmental factors on the expression and activity of human cytochrome P450 2D6 and implications in precision medicine.Systematic tissue-specific functional annotation of the human genome highlights immune-related DNA elements for late-onset Alzheimer's disease.Inhibition of Poly(ADP-ribose) Polymerase-1 Enhances Gene Expression of Selected Sirtuins and APP Cleaving Enzymes in Amyloid Beta Cytotoxicity.Heme oxygenase-1 derived carbon monoxide suppresses Aβ1-42 toxicity in astrocytes.Aggregation of the Inflammatory S100A8 Precedes Aβ Plaque Formation in Transgenic APP Mice: Positive Feedback for S100A8 and Aβ Productions.Adeno-Associated Virus-Based Gene Therapy for CNS Diseases.Omega-3 Polyunsaturated Fatty Acids and Oxylipins in Neuroinflammation and Management of Alzheimer Disease.Brain MRI-markers Associate Differentially with Cognitive Versus Functional Decline Leading to Dementia.Prevention studies in Alzheimer's disease: progress towards the development of new therapeutics.State of Play in Alzheimer's Disease Genetics.Early Growth Response 1 (Egr-1) Is a Transcriptional Activator of β-Secretase 1 (BACE-1) in the BrainBis(propyl)-cognitin Prevents β-amyloid-induced Memory Deficits as Well as Synaptic Formation and Plasticity Impairments via the Activation of PI3-K Pathway.Computational identification of potential multi-drug combinations for reduction of microglial inflammation in Alzheimer disease.Factors that influence the levels of cerebrospinal fluid biomarkers in memory clinic patients.Diversity of Amyloid-beta Proteoforms in the Alzheimer's Disease Brain.An evaluation of progressive amyloidogenic and pro-inflammatory change in the primary visual cortex and retina in Alzheimer's disease (AD).Editorial: Computational and Experimental Approaches in Multi-target Pharmacology.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Pathways to Alzheimer's disease.
@en
type
label
Pathways to Alzheimer's disease.
@en
prefLabel
Pathways to Alzheimer's disease.
@en
P2860
P50
P356
P1476
Pathways to Alzheimer's disease.
@en
P2093
N Andreasen
N Bogdanovic
P2860
P304
P356
10.1111/JOIM.12192
P407
P577
2014-03-01T00:00:00Z