Volasertib for the treatment of acute myeloid leukemia: a review of preclinical and clinical development.
about
Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoniPLK1 is a critical determinant of tumor cell sensitivity to CPT11 and its inhibition enhances the drug antitumor efficacy in squamous cell carcinoma models sensitive and resistant to camptothecins.Recent Advances and New Strategies in Targeting Plk1 for Anticancer TherapySelective blockade of cancer cell proliferation and anchorage-independent growth by Plk1 activity-dependent suicidal inhibition of its polo-box domainNew treatment for acute myelogenous leukemia.Emerging therapeutic targets for the treatment of human acute myeloid leukemia (part 1) - gene transcription, cell cycle regulation, metabolism and intercellular communication.Emerging strategies for the treatment of older patients with acute myeloid leukemia.The polo-like kinase 1 inhibitor volasertib synergistically increases radiation efficacy in glioma stem cells.
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Volasertib for the treatment of acute myeloid leukemia: a review of preclinical and clinical development.
description
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name
Volasertib for the treatment o ...... ical and clinical development.
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type
label
Volasertib for the treatment o ...... ical and clinical development.
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prefLabel
Volasertib for the treatment o ...... ical and clinical development.
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Volasertib for the treatment o ...... ical and clinical development.
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P2093
Melanie Janning
Walter Fiedler
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P304
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10.2217/FON.14.53
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P577
2014-05-01T00:00:00Z