G-quadruplex interacting small molecules and drugs: from bench toward bedside.
about
Computational understanding and experimental characterization of twice-as-smart quadruplex ligands as chemical sensors of bacterial nucleotide second messengersA Nitroxide-Tagged Platinum(II) Complex Enables the Identification of a DNA G-Quadruplex Binding ModePrefolded Synthetic G-Quartets Display Enhanced Bioinspired Properties.Nucleolin directly mediates Epstein-Barr virus immune evasion through binding to G-quadruplexes of EBNA1 mRNAConformations of Human Telomeric G-Quadruplex Studied Using a Nucleotide-Independent Nitroxide LabelIntragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevanceA General Method for Nucleophilic Aromatic Substitution of Aryl Fluorides and Chlorides with Dimethylamine using Hydroxide-Assisted Decomposition of N,N-Dimethylforamide.Preparation of 6/8/11-Amino/Chloro-Oxoisoaporphine and Group-10 Metal Complexes and Evaluation of Their in Vitro and in Vivo Antitumor ActivityTargeting of RET oncogene by naphthalene diimide-mediated gene promoter G-quadruplex stabilization exerts anti-tumor activity in oncogene-addicted human medullary thyroid cancer.Template-Mediated Stabilization of a DNA G-Quadruplex formed in the HIV-1 Promoter and Comparative Binding Studies.Templated Formation of Discrete RNA and DNA:RNA Hybrid G-Quadruplexes and Their Interactions with Targeting Ligands.Polyamine-DNA interactions and development of gene delivery vehicles.Telomeres and telomerase in prostate cancer development and therapy.Binding of anticancer drug daunomycin to a TGGGGT G-quadruplex DNA probed by all-atom molecular dynamics simulations: additional pure groove binding mode and implications on designing more selective G-quadruplex ligands.Targeting multiple effector pathways in pancreatic ductal adenocarcinoma with a G-quadruplex-binding small molecule.Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders.TWJ-Screen: an isothermal screening assay to assess ligand/DNA junction interactions in vitro.Enantioselective targeting left-handed Z-G-quadruplex.Surface-promoted aggregation of amphiphilic quadruplex ligands drives their selectivity for alternative DNA structures.Molecular Recognition of Parallel DNA Quadruplex d(TTAGGGT)4 by Mitoxantrone: Binding with 1:2 Stoichiometry Leading to Thermal Stabilization and Telomerase Inhibition.Development of microfluidic platforms for the synthesis of metal complexes and evaluation of their DNA affinity using online FRET melting assays.
P2860
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P2860
G-quadruplex interacting small molecules and drugs: from bench toward bedside.
description
2014 nî lūn-bûn
@nan
2014年の論文
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2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
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2014年論文
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2014年论文
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2014年论文
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name
G-quadruplex interacting small molecules and drugs: from bench toward bedside.
@en
type
label
G-quadruplex interacting small molecules and drugs: from bench toward bedside.
@en
prefLabel
G-quadruplex interacting small molecules and drugs: from bench toward bedside.
@en
P2860
P1476
G-quadruplex interacting small molecules and drugs: from bench toward bedside.
@en
P2860
P304
P356
10.1586/17512433.2014.945909
P407
P577
2014-08-04T00:00:00Z