Development of inhibitors of the 2C-methyl-D-erythritol 4-phosphate (MEP) pathway enzymes as potential anti-infective agents.
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Molecular docking as a popular tool in drug design, an in silico travelTargeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with β-Arylpropyl Analogues of FosmidomycinNew Insight into Isoprenoids Biosynthesis Process and Future Prospects for Drug Designing in PlasmodiumDetermination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initial structure-activity studiesHydroxybenzaldoximes Are D-GAP-Competitive Inhibitors of E. coli 1-Deoxy-D-Xylulose-5-Phosphate SynthaseMechanistic binding insights for 1-deoxy-D-Xylulose-5-Phosphate synthase, the enzyme catalyzing the first reaction of isoprenoid biosynthesis in the malaria-causing protists, Plasmodium falciparum and Plasmodium vivax.Synthesis and biological evaluation of pyrazolopyrimidines as potential antibacterial agentsMEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis.Challenges and Hallmarks of Establishing Alkylacetylphosphonates as Probes of Bacterial 1-Deoxy-d-xylulose 5-Phosphate Synthase.Validation of a homology model of Mycobacterium tuberculosis DXS: rationalization of observed activities of thiamine derivatives as potent inhibitors of two orthologues of DXS.Molecular cloning and expression analysis of two key genes, HDS and HDR, in the MEP pathway in Pyropia haitanensis.Further Insight into Crystal Structures of Escherichia coli IspH/LytB in Complex with Two Potent Inhibitors of the MEP Pathway: A Starting Point for Rational Design of New Antimicrobials.Phage Display on the Anti-infective Target 1-Deoxy-d-xylulose-5-phosphate Synthase Leads to an Acceptor-Substrate Competitive Peptidic Inhibitor.Crystal structure of IspF from Bacillus subtilis and absence of protein complex assembly among IspD/IspE/IspF enzymes in the MEP pathway.(Z)-4-Chloro-N-{3-[(4-chlorophenyl)sulfonyl]-2,3-dihydrobenzo[d]thiazol-2-ylidene}benzene-sulfonamide.Growth medium-dependent antimicrobial activity of early stage MEP pathway inhibitors.An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets.Acyloxybenzyl and Alkoxyalkyl Prodrugs of a Fosmidomycin Surrogate as Antimalarial and Antitubercular Agents
P2860
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P2860
Development of inhibitors of the 2C-methyl-D-erythritol 4-phosphate (MEP) pathway enzymes as potential anti-infective agents.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Development of inhibitors of t ...... tential anti-infective agents.
@en
type
label
Development of inhibitors of t ...... tential anti-infective agents.
@en
prefLabel
Development of inhibitors of t ...... tential anti-infective agents.
@en
P356
P1476
Development of inhibitors of t ...... otential anti-infective agents
@en
P2093
Tiziana Masini
P304
P356
10.1021/JM5010978
P407
P577
2014-09-25T00:00:00Z