Drug-induced mitochondrial impairment in liver cells.

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Pathophysiology of cholestatic liver disease and its relevance for in vitro tests of hepatotoxicity.Highlight report: Metabolomics in hepatotoxicity testing.Highlight report: Monitoring cytochrome P450 activities in living hepatocytes.

P2860

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Drug-induced mitochondrial impairment in liver cells.

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http://www.wikidata.org/entity/Q38269291

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2015 nî lūn-bûn

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2015年の論文

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2015年学术文章

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2015年学术文章

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name

Drug-induced mitochondrial impairment in liver cells.

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type

Item

label

Drug-induced mitochondrial impairment in liver cells.

@en

prefLabel

Drug-induced mitochondrial impairment in liver cells.

@en

P1476

Drug-induced mitochondrial impairment in liver cells.

@en

P2093

Regina Stöber

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Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening.

Cryopreserved primary hepatocytes as a constantly available in vitro model for the evaluation of human and animal drug metabolism and enzyme induction.

Screening of repeated dose toxicity data present in SCC(NF)P/SCCS safety evaluations of cosmetic ingredients.

Gemfibrozil disrupts lysophosphatidylcholine and bile acid homeostasis via PPARα and its relevance to hepatotoxicity.

Toxicogenomics directory of chemically exposed human hepatocytes.

Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies.

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

Mechanisms of amiodarone and valproic acid induced liver steatosis in mouse in vivo act as a template for other hepatotoxicity models.

Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells.

P304

1297-1299

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scholarly article

editorial

P356

10.17179/EXCLI2015-764

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2015-12-22T00:00:00Z

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26862331

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P932

4743473

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Drug-induced mitochondrial impairment in liver cells.

about

P2860

P2860

Drug-induced mitochondrial impairment in liver cells.

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P478

P577

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P478

P577

P698

P932