Transmembrane signal transduction of the alpha(IIb)beta(3) integrin.
about
Involvement of transmembrane domain interactions in signal transduction by alpha/beta integrinsDisruption of the integrin alphaLbeta2 transmembrane domain interface by beta2 Thr-686 mutation activates alphaLbeta2 and promotes micro-clustering of the alphaL subunitsDimerization of the transmembrane domain of Integrin alphaIIb subunit in cell membranesStructure and function of the platelet integrin alphaIIbbeta3Quantification of helix-helix binding affinities in micelles and lipid bilayersA specific interface between integrin transmembrane helices and affinity for ligandDetermination of N- and C-terminal borders of the transmembrane domain of integrin subunits.Prediction of transmembrane helix orientation in polytopic membrane proteins.Stepped changes of monovalent ligand-binding force during ligand-induced clustering of integrin alphaIIB beta3.Integrin alphaIIbbeta3:ligand interactions are linked to binding-site remodeling.A push-pull mechanism for regulating integrin function.Structural basis of transmembrane domain interactions in integrin signaling.Transmembrane and cytoplasmic domains in integrin activation and protein-protein interactions (review).Tests of integrin transmembrane domain homo-oligomerization during integrin ligand binding and signalingTransmembrane and Juxtamembrane Structure of αL Integrin in Bicelles.Conformational changes in talin on binding to anionic phospholipid membranes facilitate signaling by integrin transmembrane helicesIntegrins, cations and ligands: making the connection.Integrin αIIbβ3 transmembrane domain separation mediates bi-directional signaling across the plasma membrane.On the activation of integrin αIIbβ3: outside-in and inside-out pathways.Multiple approaches converge on the structure of the integrin alphaIIb/beta3 transmembrane heterodimer.Interaction and conformational dynamics of membrane-spanning protein helices.Integrin bi-directional signaling across the plasma membrane.Intramembrane attenuation of the TLR4-TLR6 dimer impairs receptor assembly and reduces microglia-mediated neurodegeneration.Genetic analysis of beta1 integrin "activation motifs" in mice.Exploring the Role of RGD-Recognizing Integrins in Cancer.Solution properties of full-length integrin alpha(IIb)beta3 refined models suggest environment-dependent induction of alternative bent /extended resting states.Force-induced destabilization of focal adhesions at defined integrin spacings on nanostructured surfaces.Transmembrane helices that form two opposite homodimeric interactions: an asparagine scan study of alphaM and beta2 integrins.Transmembrane domain helix packing stabilizes integrin alphaIIbbeta3 in the low affinity state.Evidence for hetero-association of transmembrane helices of integrins.On the contributing role of the transmembrane domain for subunit-specific sensitivity of integrin activation.
P2860
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P2860
Transmembrane signal transduction of the alpha(IIb)beta(3) integrin.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Transmembrane signal transduction of the alpha(IIb)beta(3) integrin.
@en
type
label
Transmembrane signal transduction of the alpha(IIb)beta(3) integrin.
@en
prefLabel
Transmembrane signal transduction of the alpha(IIb)beta(3) integrin.
@en
P2860
P356
P1433
P1476
Transmembrane signal transduction of the alpha(IIb)beta(3) integrin.
@en
P2093
Horst Kessler
Kay E Gottschalk
P2860
P304
P356
10.1110/PS.4120102
P577
2002-07-01T00:00:00Z