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Pim kinases in hematological malignancies: where are we now and where are we going?

Pim kinases in hematological malignancies: where are we now and where are we going?

http://www.wikidata.org/entity/Q38285805

about

Mantle cell lymphoma in the era of precision medicine-diagnosis, biomarkers and therapeutic agents Pim-1 kinase as cancer drug target: An update Pim Kinase Interacts with Nonstructural 5A Protein and Regulates Hepatitis C Virus Entry.Approved and Experimental Small-Molecule Oncology Kinase Inhibitor Drugs: A Mid-2016 Overview.Inflammation and stem markers association to PIM1/PIM2 kinase-induced tumors in breast and uterus.Control of translational activation by PIM kinase in activated B-cell diffuse large B-cell lymphoma confers sensitivity to inhibition by PIM447.Mutational profile of primary breast diffuse large B-cell lymphoma.FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway.PIM-2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity.Preclinical characterization of INCB053914, a novel pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in models of hematologic malignancies.TRAF3 as a Multifaceted Regulator of B Lymphocyte Survival and Activation

P2860

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P2860

Pim kinases in hematological malignancies: where are we now and where are we going?

http://www.wikidata.org/entity/Q38285805

description

2014 nî lūn-bûn

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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2014年论文

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name

Pim kinases in hematological malignancies: where are we now and where are we going?

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Pim kinases in hematological malignancies: where are we now and where are we going?

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Pim kinases in hematological malignancies: where are we now and where are we going?

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Journal of Hematology & Oncology

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Pim kinases in hematological malignancies: where are we now and where are we going?

@en

P2093

Michael Mian

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Creative Commons Attribution

P2860

Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL

Pim-2 phosphorylation of p21(Cip1/WAF1) enhances its stability and inhibits cell proliferation in HCT116 cells

Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels

Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongation

Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas.

Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors

Widespread microRNA repression by Myc contributes to tumorigenesis

Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity

Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

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scholarly article

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10.1186/S13045-014-0095-Z

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7

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Salvatore Cuzzocrea

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2014-12-10T00:00:00Z

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269466962

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1014879315

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25491234

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hematologic cancer

proto-oncogene proteins

neoplasm proteins

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4266197

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