Towards improved oligonucleotide therapeutics through faster target binding kinetics.

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Towards improved oligonucleotide therapeutics through faster target binding kinetics.

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年學術文章

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Towards improved oligonucleotide therapeutics through faster target binding kinetics.

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Towards improved oligonucleotide therapeutics through faster target binding kinetics.

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Towards improved oligonucleotide therapeutics through faster target binding kinetics.

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P1476

Towards improved oligonucleotide therapeutics through faster target binding kinetics.

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P2093

Andreas Brunschweiger

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Anna L Malinowska

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Bettina Wild

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Helen Louise Lightfoot

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Jonathan Hall

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Mirjam Menzi

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Ugo Pradère

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P2860

Crystal structures of DNA:DNA and DNA:RNA duplexes containing 5-(N-aminohexyl)carbamoyl-modified uracils reveal the basis for properties as antigene and antisense molecules

Polyaminooligonucleotide: NMR structure of duplex DNA containing a nucleoside with spermine residue, N-[4,9,13-triazatridecan-1-yl]-2'-deoxycytidine

Treatment of infantile-onset spinal muscular atrophy with nusinersen: a phase 2, open-label, dose-escalation study.

Analysis of thermal melting curves.

Polyamines: mysterious modulators of cellular functions.

Clinical and preclinical pharmacokinetics and pharmacodynamics of mipomersen (kynamro(®)): a second-generation antisense oligonucleotide inhibitor of apolipoprotein B

Surface plasmon resonance biosensor for rapid label-free detection of microribonucleic acid at subfemtomole level.

Antisense and antigene inhibition of gene expression by cell-permeable oligonucleotide-oligospermine conjugates.

Site-specific conjugation of drug-like fragments to an antimiR scaffold as a strategy to target miRNAs inside RISC.

Drug-target residence time and its implications for lead optimization.

P31

scholarly article

P356

10.1002/CHEM.201701670

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English

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2017-07-26T00:00:00Z

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28746731

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