Desensitization and internalization of the m2 muscarinic acetylcholine receptor are directed by independent mechanisms.
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Dynamin mediates caveolar sequestration of muscarinic cholinergic receptors and alteration in NO signalingAcidic amino acids flanking phosphorylation sites in the M2 muscarinic receptor regulate receptor phosphorylation, internalization, and interaction with arrestinsA Ser/Thr cluster within the C-terminal domain of the rat prostaglandin receptor EP3alpha is essential for agonist-induced phosphorylation, desensitization and internalizationPurification of A1 adenosine receptor-G-protein complexes: effects of receptor down-regulation and phosphorylation on couplingThreonine 180 is required for G-protein-coupled receptor kinase 3- and beta-arrestin 2-mediated desensitization of the mu-opioid receptor in Xenopus oocytes.G-protein coupled receptor kinases as modulators of G-protein signalling.Internalization and sequestration of the human prostacyclin receptor.Internalization of the human nicotinic acid receptor GPR109A is regulated by G(i), GRK2, and arrestin3.Agonist mediated internalization of M2 mAChR is beta-arrestin-dependentThe G protein-coupled receptors: pharmacogenetics and disease.Evidence that the nucleotide exchange and hydrolysis cycle of G proteins causes acute desensitization of G-protein gated inward rectifier K+ channelsA dileucine motif in the C terminus of the beta2-adrenergic receptor is involved in receptor internalization.Arrestin binds to different phosphorylated regions of the thyrotropin-releasing hormone receptor with distinct functional consequences.G-protein-coupled receptor kinase 2 terminates G-protein-coupled receptor function in steroid hormone 20-hydroxyecdysone signaling.Identification of an Ascaris G protein-coupled acetylcholine receptor with atypical muscarinic pharmacologyIntragenic suppression of a constitutively active allele of Gsα associated with McCune-Albright syndrome.Non-neuronal functions of the m2 muscarinic acetylcholine receptor.A dominant-negative strategy for studying roles of G proteins in vivo.Cholinergic modulation of the hippocampal region and memory function.Uncoupling and endocytosis of 5-hydroxytryptamine 4 receptors. Distinct molecular events with different GRK2 requirements.G protein-coupled receptor kinase 2-mediated phosphorylation of ezrin is required for G protein-coupled receptor-dependent reorganization of the actin cytoskeleton.The RGS (regulator of G-protein signalling) and GoLoco domains of RGS14 co-operate to regulate Gi-mediated signalling.Identification of a Ser/Thr cluster in the C-terminal domain of the human prostaglandin receptor EP4 that is essential for agonist-induced beta-arrestin1 recruitment but differs from the apparent principal phosphorylation site.G alpha COOH-terminal minigene vectors dissect heterotrimeric G protein signaling.Partial phosphorylation of the N-formyl peptide receptor inhibits G protein association independent of arrestin binding.Role of hydroxyl containing residues in the intracellular region of rat bradykinin B(2) receptor in signal transduction, receptor internalization, and resensitization.Deltorphin II-induced rapid desensitization of delta-opioid receptor requires both phosphorylation and internalization of the receptor.Arrestin binding to the M(2) muscarinic acetylcholine receptor is precluded by an inhibitory element in the third intracellular loop of the receptor.Revisiting the endocytosis of the m2 muscarinic acetylcholine receptor.Effect of G protein-coupled receptor kinase 2 on the sensitivity of M4 muscarinic acetylcholine receptors to agonist-induced internalization and desensitization in NG108-15 cells.Receptor-mediated internalization is critical for the inhibition of the expression of growth hormone by somatostatin in the pituitary cell line AtT-20.Regulation of muscarinic acetylcholine receptor sequestration and function by beta-arrestin.Signaling and phosphorylation-impaired mutants of the rat follitropin receptor reveal an activation- and phosphorylation-independent but arrestin-dependent pathway for internalization.Receptor subtype-specific regulation of muscarinic acetylcholine receptor sequestration by dynamin. Distinct sequestration of m2 receptors.Arrestin-independent internalization of the m1, m3, and m4 subtypes of muscarinic cholinergic receptors.Internalization of the m2 muscarinic acetylcholine receptor. Arrestin-independent and -dependent pathways.Two homologous phosphorylation domains differentially contribute to desensitization and internalization of the m2 muscarinic acetylcholine receptor.Beta-adrenergic receptor kinase (GRK2) colocalizes with beta-adrenergic receptors during agonist-induced receptor internalization.GTP-binding-protein-coupled receptor kinases--two mechanistic models.Identification of an essential amino acid motif within the C terminus of the pituitary adenylate cyclase-activating polypeptide type I receptor that is critical for signal transduction but not for receptor internalization.
P2860
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P2860
Desensitization and internalization of the m2 muscarinic acetylcholine receptor are directed by independent mechanisms.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
Desensitization and internaliz ...... ted by independent mechanisms.
@en
type
label
Desensitization and internaliz ...... ted by independent mechanisms.
@en
prefLabel
Desensitization and internaliz ...... ted by independent mechanisms.
@en
P2093
P356
P1476
Desensitization and internaliz ...... cted by independent mechanisms
@en
P2093
J L Benovic
R Pals-Rylaarsdam
P304
29004-29011
P356
10.1074/JBC.270.48.29004
P407
P577
1995-12-01T00:00:00Z