High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia.
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The PEBP2betaMYH11 fusion created by Inv(16)(p13;q22) in myeloid leukemia impairs neutrophil maturation and contributes to granulocytic dysplasiaThe novel ETS factor TEL2 cooperates with Myc in B lymphomagenesisThe acetyltransferase 60 kDa trans-acting regulatory protein of HIV type 1-interacting protein (Tip60) interacts with the translocation E26 transforming-specific leukaemia gene (TEL) and functions as a transcriptional co-repressorDisruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesisGenetic studies of a cluster of acute lymphoblastic leukemia cases in Churchill County, NevadaMolecular mechanisms of ETS transcription factor-mediated tumorigenesisCore-binding factor influences the disease specificity of Moloney murine leukemia virusTreatment of adolescent and young adults with acute lymphoblastic leukemiaBoth TEL and AML-1 contribute repression domains to the t(12;21) fusion protein.TEL, a putative tumor suppressor, modulates cell growth and cell morphology of ras-transformed cells while repressing the transcription of stromelysin-1.The leukemogenic t(8;21) fusion protein AML1-ETO controls rRNA genes and associates with nucleolar-organizing regions at mitotic chromosomes.Proteomic profile of pre - B2 lymphoblasts from children with acute lymphoblastic leukemia (ALL) in relation with the translocation (12; 21)Chromosome translocations and covert leukemic clones are generated during normal fetal developmentPresence of clone-specific markers at birth in children with acute lymphoblastic leukaemia.TEL-AML1 transgenic zebrafish model of precursor B cell acute lymphoblastic leukemia.Neonatal infection with species C adenoviruses confirmed in viable cord blood lymphocytes.A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth.Prospective analysis of TEL gene rearrangements in childhood acute lymphoblastic leukemia: a Children's Oncology Group study.Transcriptome sequencing reveals CHD1 as a novel fusion partner of RUNX1 in acute myeloid leukemia with t(5;21)(q21;q22).The t(1;12)(q21;p13) translocation of human acute myeloblastic leukemia results in a TEL-ARNT fusion.Prospective analysis of TEL/AML1-positive patients treated on Dana-Farber Cancer Institute Consortium Protocol 95-01.Functional characterization of ETV6 and ETV6/CBFA2 in the regulation of the MCSFR proximal promoterIdentification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF-alpha transcription factors.Ovarian cancer has frequent loss of heterozygosity at chromosome 12p12.3-13.1 (region of TEL and Kip1 loci) and chromosome 12q23-ter: evidence for two new tumour-suppressor genesMolecular pathophysiology of myelodysplastic syndromes.Fetal origins of the TEL-AML1 fusion gene in identical twins with leukemia.The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription.Human AML1/MDS1/EVI1 fusion protein induces an acute myelogenous leukemia (AML) in mice: a model for human AMLThe TEL-AML1 leukemia fusion gene dysregulates the TGF-beta pathway in early B lineage progenitor cells.Genomic and proteomic biomarkers for cancer: a multitude of opportunities.Cytotoxic T cell response against the chimeric ETV6-AML1 protein in childhood acute lymphoblastic leukemia.Copy number genome alterations are associated with treatment response and outcome in relapsed childhood ETV6/RUNX1-positive acute lymphoblastic leukemia.Cytogenetic and molecular predictors of outcome in acute lymphocytic leukemia: recent developments.The RUNX family in breast cancer: relationships with estrogen signaling.CD10 is a marker for cycling cells with propensity to apoptosis in childhood ALLETS-core binding factor: a common composite motif in antigen receptor gene enhancers.Classification of acute leukaemia: the need to incorporate cytogenetic and molecular genetic information.The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation.Modeling the evolution of ETV6-RUNX1-induced B-cell precursor acute lymphoblastic leukemia in mice.Tel, a frequent target of leukemic translocations, induces cellular aggregation and influences expression of extracellular matrix components.
P2860
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P2860
High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia.
@en
type
label
High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia.
@en
prefLabel
High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia.
@en
P2093
P1433
P1476
High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia
@en
P2093
Jonveaux P
Leconiat M
Macintyre EA
Mauchauffé M
P304
P407
P577
1995-12-01T00:00:00Z