Aminoglycosides modified by resistance enzymes display diminished binding to the bacterial ribosomal aminoacyl-tRNA site.
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Structure and Functional Diversity of GCN5-Related N-Acetyltransferases (GNAT)Kinetic and Structural Analysis of Bisubstrate Inhibition of the Salmonella enterica Aminoglycoside 6‘- N -Acetyltransferase † , ‡Structural Basis of APH(3')-IIIa-Mediated Resistance to N1-Substituted Aminoglycoside AntibioticsStructural analysis of a putative aminoglycoside N-acetyltransferase from Bacillus anthracis.Structure of the phosphotransferase domain of the bifunctional aminoglycoside-resistance enzyme AAC(6′)-Ie-APH(2′′)-IaComparing aminoglycoside binding sites in bacterial ribosomal RNA and aminoglycoside modifying enzymes.Two-dimensional combinatorial screening identifies specific 6'-acylated kanamycin A- and 6'-acylated neamine-RNA hairpin interactions.Two-dimensional combinatorial screening and the RNA Privileged Space Predictor program efficiently identify aminoglycoside-RNA hairpin loop interactionsA fluorescence-based screen for ribosome binding antibiotics.Aminoglycoside resistance rates, phenotypes, and mechanisms of Gram-negative bacteria from infected patients in upper Egypt.Defining RNA motif-aminoglycoside interactions via two-dimensional combinatorial screening and structure-activity relationships through sequencing.Characterization of ribosomal binding and antibacterial activities using two orthogonal high-throughput screensMultidrug efflux pumps from Enterobacteriaceae, Vibrio cholerae and Staphylococcus aureus bacterial food pathogensVersatility of aminoglycosides and prospects for their future.Rate of isolation and trends of antimicrobial resistance of multidrug resistant pseudomonas aeruginosa from otorrhea in chronic suppurative otitis media.Tools for glycomics: mapping interactions of carbohydrates in biological systems.Rational Design of Small Molecules Targeting Oncogenic Noncoding RNAs from Sequence.Revisiting the nucleotide and aminoglycoside substrate specificity of the bifunctional aminoglycoside acetyltransferase(6')-Ie/aminoglycoside phosphotransferase(2'')-Ia enzyme.In vitro antibacterial activity of vertilmicin and its susceptibility to modifications by the recombinant AAC6'-APH2'' enzyme.Quorum-sensing control of antibiotic synthesis in Burkholderia thailandensisStudying modification of aminoglycoside antibiotics by resistance-causing enzymes via microarray.Fluorescently labeled ribosomes as a tool for analyzing antibiotic binding.Studying aminoglycoside modification by the acetyltransferase class of resistance-causing enzymes via microarray.Double-stranded RNA-binding artificial cationic oligosaccharides stabilizing siRNAs with a low N/P ratio.The molecular basis of the expansive substrate specificity of the antibiotic resistance enzyme aminoglycoside acetyltransferase-6'-aminoglycoside phosphotransferase-2". The role of ASP-99 as an active site base important for acetyl transfer.A toxic RNA catalyzes the in cellulo synthesis of its own inhibitor.Aminoglycosides: An Overview.The Complex Relationship between Virulence and Antibiotic Resistance.Aminoglycoside resistance resulting from tight drug binding to an altered aminoglycoside acetyltransferaseStructure of AadA from Salmonella enterica: a monomeric aminoglycoside (3'')(9) adenyltransferase.The kinetic mechanism of AAC3-IV aminoglycoside acetyltransferase from Escherichia coli.Source of phosphate in the enzymic reaction as a point of distinction among aminoglycoside 2''-phosphotransferases.Activity-based substrate profiling for Gcn5-related N-acetyltransferases: the use of chloroacetyl-coenzyme A to identify protein substrates.Small-angle X-ray scattering analysis of the bifunctional antibiotic resistance enzyme aminoglycoside (6') acetyltransferase-ie/aminoglycoside (2'') phosphotransferase-ia reveals a rigid solution structure.A modified fluorescent intercalator displacement assay for RNA ligand discovery.Selection of peptides that target the aminoacyl-tRNA site of bacterial 16S ribosomal RNA.Ligand- and pH-induced conformational changes of RNA domain helix 69 revealed by 2-aminopurine fluorescence.Antimicrobial resistance mechanisms among Campylobacter.Using Genome Sequence to Enable the Design of Medicines and Chemical Probes.Enhanced production of validamycin A in Streptomyces hygroscopicus 5008 by engineering validamycin biosynthetic gene cluster.
P2860
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P2860
Aminoglycosides modified by resistance enzymes display diminished binding to the bacterial ribosomal aminoacyl-tRNA site.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Aminoglycosides modified by re ...... ribosomal aminoacyl-tRNA site.
@en
type
label
Aminoglycosides modified by re ...... ribosomal aminoacyl-tRNA site.
@en
prefLabel
Aminoglycosides modified by re ...... ribosomal aminoacyl-tRNA site.
@en
P2093
P1476
Aminoglycosides modified by re ...... ribosomal aminoacyl-tRNA site.
@en
P2093
Beatriz Llano-Sotelo
Christine S Chow
Eduardo F Azucena
Lakshmi P Kotra
Shahriar Mobashery
P304
P356
10.1016/S1074-5521(02)00125-4
P577
2002-04-01T00:00:00Z