Structural requirements for the binding of tRNA Lys3 to reverse transcriptase of the human immunodeficiency virus type 1.
about
The connection domain in reverse transcriptase facilitates the in vivo annealing of tRNALys3 to HIV-1 genomic RNAThe structure of the human tRNALys3 anticodon bound to the HIV genome is stabilized by modified nucleosides and adjacent mismatch base pairsHIV-1 A-rich RNA loop mimics the tRNA anticodon structureInhibitors of human immunodeficiency virus type 1 reverse transcriptase target distinct phases of early reverse transcriptionPhosphorothioate oligonucleotides derived from human immunodeficiency virus type 1 (HIV-1) primer tRNALys3 are strong inhibitors of HIV-1 reverse transcriptase and arrest viral replication in infected cellsFunctional domains of Tat required for efficient human immunodeficiency virus type 1 reverse transcription.The roles of the human immunodeficiency virus type 1 Pol protein and the primer binding site in the placement of primer tRNA(3Lys) onto viral genomic RNA.Heterogeneous structures formed by conserved RNA sequences within the HIV reverse transcription initiation site.Variation of human immunodeficiency virus type-1 reverse transcriptase within the simian immunodeficiency virus genome of RT-SHIV.Mutating a region of HIV-1 reverse transcriptase implicated in tRNA(Lys-3) binding and the consequences for (-)-strand DNA synthesis.Inhibition of HIV-1 replication using a mutated tRNALys-3 primer.On the importance of the primer activation signal for initiation of tRNA(lys3)-primed reverse transcription of the HIV-1 RNA genome.Essential regions of the tRNA primer required for HIV-1 infectivityForced selection of a human immunodeficiency virus type 1 variant that uses a non-self tRNA primer for reverse transcription: involvement of viral RNA sequences and the reverse transcriptase enzyme.RNA-protein interactions in the regulation of coronavirus RNA replication and transcription.Switching the in vitro tRNA usage of HIV-1 by simultaneous adaptation of the PBS and PAS.Role of the primer activation signal in tRNA annealing onto the HIV-1 genome studied by single-molecule FRET microscopy.The availability of the primer activation signal (PAS) affects the efficiency of HIV-1 reverse transcription initiation.In vitro studies on tRNA annealing and reverse transcription with mutant HIV-1 RNA templates.
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P2860
Structural requirements for the binding of tRNA Lys3 to reverse transcriptase of the human immunodeficiency virus type 1.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
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name
Structural requirements for th ...... immunodeficiency virus type 1.
@en
type
label
Structural requirements for th ...... immunodeficiency virus type 1.
@en
prefLabel
Structural requirements for th ...... immunodeficiency virus type 1.
@en
P2093
P2860
P356
P1476
Structural requirements for th ...... immunodeficiency virus type 1.
@en
P2093
Berkhout B
Oude Essink BB
P2860
P304
23867-23874
P356
10.1074/JBC.270.40.23867
P407
P577
1995-10-01T00:00:00Z