Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity.
about
Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseasesDifferential modulation of the human liver conjugate transporters MRP2 and MRP3 by bile acids and organic anionsMolecular docking simulations provide insights in the substrate binding sites and possible substrates of the ABCC6 transporterRole of the NH2-terminal membrane spanning domain of multidrug resistance protein 1/ABCC1 in protein processing and traffickingCyanobacterial cyclopeptides as lead compounds to novel targeted cancer drugsHigh incidence of methotrexate associated renal toxicity in patients with lymphoma: a retrospective analysis.Multidrug resistance protein 1 (MRP1, ABCC1), a "multitasking" ATP-binding cassette (ABC) transporter.Use of tc-99m mebrofenin as a clinical probe to assess altered hepatobiliary transport: integration of in vitro, pharmacokinetic modeling, and simulation studies.Photoaffinity labeling of the multidrug resistance protein 2 (ABCC2/cMOAT) with a photoreactive analog of LTC(4)Expression of resistance markers to methotrexate predicts clinical improvement in patients with rheumatoid arthritisPore-exposed tyrosine residues of P-glycoprotein are important hydrogen-bonding partners for drugs.Endothelial progenitor cells in chronic obstructive pulmonary disease and emphysemaP-glycoprotein is fully active after multiple tryptophan substitutionsFunctional analysis of nonsynonymous single nucleotide polymorphisms of multidrug resistance-associated protein 2 (ABCC2).Chalcogenopyrylium dyes as differential modulators of organic anion transport by multidrug resistance protein 1 (MRP1), MRP2, and MRP4ABCB1 and ABCC11 confer resistance to eribulin in breast cancer cell lines.Transporter pharmacogenetics: transporter polymorphisms affect normal physiology, diseases, and pharmacotherapyDeterminants of the substrate specificity of multidrug resistance protein 1: role of amino acid residues with hydrogen bonding potential in predicted transmembrane helix 17.Selenium-dependent and -independent transport of arsenic by the human multidrug resistance protein 2 (MRP2/ABCC2): implications for the mutual detoxification of arsenic and selenium.Molecular expression and functional evidence of a drug efflux pump (BCRP) in human corneal epithelial cells.Identification and characterization of functionally important elements in the multidrug resistance protein 1 COOH-terminal region.Arsenic transport by the human multidrug resistance protein 1 (MRP1/ABCC1). Evidence that a tri-glutathione conjugate is required.Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2).Multiple membrane-associated tryptophan residues contribute to the transport activity and substrate specificity of the human multidrug resistance protein, MRP1.cAMP induces ABCA1 phosphorylation activity and promotes cholesterol efflux from fibroblasts.Role of ABCC2 common variants in intrahepatic cholestasis of pregnancy.GSH-dependent photolabeling of multidrug resistance protein MRP1 (ABCC1) by [125I]LY475776. Evidence of a major binding site in the COOH-proximal membrane spanning domain.Charged amino acids in the sixth transmembrane helix of multidrug resistance protein 1 (MRP1/ABCC1) are critical determinants of transport activity.Identification of domains participating in the substrate specificity and subcellular localization of the multidrug resistance proteins MRP1 and MRP2.
P2860
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P2860
Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Mutation of Trp1254 in the mul ...... thotrexate transport activity.
@en
type
label
Mutation of Trp1254 in the mul ...... thotrexate transport activity.
@en
prefLabel
Mutation of Trp1254 in the mul ...... thotrexate transport activity.
@en
P2093
P921
P356
P1476
Mutation of Trp1254 in the mul ...... ethotrexate transport activity
@en
P2093
P304
38108-38114
P356
10.1074/JBC.M105160200
P407
P50
P577
2001-08-10T00:00:00Z