The potent anti-HIV protein cyanovirin-N contains two novel carbohydrate binding sites that selectively bind to Man(8) D1D3 and Man(9) with nanomolar affinity: implications for binding to the HIV envelope protein gp120.
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Printed covalent glycan array for ligand profiling of diverse glycan binding proteinsStructures of the complexes of a potent anti-HIV protein cyanovirin-N and high mannose oligosaccharidesThe Novel Fold of Scytovirin Reveals a New Twist For Antiviral Entry InhibitorsConformational gating of dimannose binding to the antiviral protein cyanovirin revealed from the crystal structure at 1.35 Å resolutionSolution and Crystal Structures of a Sugar Binding Site Mutant of Cyanovirin-N: No Evidence of Domain SwappingMechanism by which the lectin actinohivin blocks HIV infection of target cellsAnti-HIV Activity of Defective Cyanovirin-N Mutants Is Restored by DimerizationNMR solution structure of a cyanovirin homolog from wheat head blight fungusSolution Structure of the Monovalent Lectin Microvirin in Complex with Man (1-2)Man Provides a Basis for Anti-HIV Activity with Low ToxicityStructural Insights into the Anti-HIV Activity of the Oscillatoria agardhii Agglutinin Homolog Lectin FamilyDesigned oligomers of cyanovirin-N show enhanced HIV neutralizationStructural insights into the specific anti-HIV property of actinohivin: structure of its complex with the α(1–2)mannobiose moiety of gp120The characteristic structure of anti-HIV actinohivin in complex with three HMTG D1 chains of HIV-gp120Glycoarray Technologies: Deciphering Interactions from Proteins to Live Cell ResponsesA flexible docking scheme efficiently captures the energetics of glycan-cyanovirin binding.Advances in the Development of Microbicides for the Prevention of HIV Infection.Resistance of human immunodeficiency virus type 1 to the high-mannose binding agents cyanovirin N and concanavalin A.The glycan shield of HIV is predominantly oligomannose independently of production system or viral clade.Microvirin, a novel alpha(1,2)-mannose-specific lectin isolated from Microcystis aeruginosa, has anti-HIV-1 activity comparable with that of cyanovirin-N but a much higher safety profile.Sugar-binding proteins potently inhibit dendritic cell human immunodeficiency virus type 1 (HIV-1) infection and dendritic-cell-directed HIV-1 transfer.Algal lectins as potential HIV microbicide candidatesThe mannose-dependent epitope for neutralizing antibody 2G12 on human immunodeficiency virus type 1 glycoprotein gp120.The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1-->2 mannose residues on the outer face of gp120.Dynamics of HIV neutralization by a microbicide formulation layer: biophysical fundamentals and transport theory.Synergistic inhibition of HIV-1 envelope-mediated membrane fusion by inhibitors targeting the N and C-terminal heptad repeats of gp41.Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability.Human Immunodeficiency Virus (HIV) Separation and Enrichment via the Combination of Antiviral Lectin Recognition and a Thermoresponsive Reagent System.Cyanovirin-N inhibits mannose-dependent Mycobacterium-C-type lectin interactions but does not protect against murine tuberculosisDirect measurement of glyconanoparticles and lectin interactions by isothermal titration calorimetryCarbohydrate recognition by the antiviral lectin cyanovirin-N.Expression, purification and identification of CtCVNH, a novel anti-HIV (Human Immunodeficiency Virus) protein from Ceratopteris thalictroidesEfficient synthesis of Man2, Man3, and Man5 oligosaccharides, using mannosyl iodide donors.Synthesis of branched Man5 oligosaccharides and an unusual stereochemical observation.A Designed "Nested" Dimer of Cyanovirin-N Increases Antiviral Activity.Vaginal microbicides and the prevention of HIV transmissionNew carbohydrate specificity and HIV-1 fusion blocking activity of the cyanobacterial protein MVL: NMR, ITC and sedimentation equilibrium studies.Multivalent glyconanoparticles with enhanced affinity to the anti-viral lectin Cyanovirin-N.Characterizing carbohydrate-protein interactions by nuclear magnetic resonance spectroscopy.Inhibition of hepatitis C virus by the cyanobacterial protein Microcystis viridis lectin: mechanistic differences between the high-mannose specific lectins MVL, CV-N, and GNA.The antiviral lectin cyanovirin-N: probing multivalency and glycan recognition through experimental and computational approaches.
P2860
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P2860
The potent anti-HIV protein cyanovirin-N contains two novel carbohydrate binding sites that selectively bind to Man(8) D1D3 and Man(9) with nanomolar affinity: implications for binding to the HIV envelope protein gp120.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
The potent anti-HIV protein cy ...... he HIV envelope protein gp120.
@en
type
label
The potent anti-HIV protein cy ...... he HIV envelope protein gp120.
@en
prefLabel
The potent anti-HIV protein cy ...... he HIV envelope protein gp120.
@en
P356
P1476
The potent anti-HIV protein cy ...... he HIV envelope protein gp120.
@en
P2093
Otero-Quintero S
P304
P356
10.1021/JA004040E
P407
P577
2001-05-01T00:00:00Z