MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis.
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The Quest for Targets Executing MYC-Dependent Cell TransformationDefective control of pre-messenger RNA splicing in human diseaseDual targeting of p53 and c-MYC selectively eliminates leukaemic stem cellsSynthetic lethality: emerging targets and opportunities in melanoma.PRMT5 regulates IRES-dependent translation via methylation of hnRNP A1.How do messenger RNA splicing alterations drive myelodysplasia?From General Aberrant Alternative Splicing in Cancers and Its Therapeutic Application to the Discovery of an Oncogenic DMTF1 Isoform.The spliceosome is a therapeutic vulnerability in MYC-driven cancer.Potential effect of spliceosome inhibition in small cell lung cancer irrespective of the MYC statusSmall Molecule Modulators of Pre-mRNA Splicing in Cancer TherapyTargeting MYC in cancer therapy: RNA processing offers new opportunities.The prognostic potential of alternative transcript isoforms across human tumors.MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells.An alternative splicing program promotes adipose tissue thermogenesisLessons from non-canonical splicingPRMT5-Selective Inhibitors Suppress Inflammatory T Cell Responses and Experimental Autoimmune Encephalomyelitis.Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666.Alternative splicing: the pledge, the turn, and the prestige : The key role of alternative splicing in human biological systems.Pharmacology of Modulators of Alternative Splicing.Splicing regulator SLU7 preserves survival of hepatocellular carcinoma cells and other solid tumors via oncogenic miR-17-92 cluster expression.The E3 ubiquitin ligase CHIP mediates ubiquitination and proteasomal degradation of PRMT5.Beyond transcription factors: how oncogenic signalling reshapes the epigenetic landscape.Splicing-factor alterations in cancers.MYC, Metabolic Synthetic Lethality, and Cancer.Targeting MDM4 Splicing in Cancers.Therapeutic targeting of splicing in cancer.KATapulting toward Pluripotency and Cancer.Unmasking the U2AF homology motif family: a bona fide protein-protein interaction motif in disguise.Splicing factor gene mutations in hematologic malignancies.Splicing Factor Mutations in Myelodysplasias: Insights from Spliceosome Structures.The role of RNA alternative splicing in regulating cancer metabolism.Emerging Role for Methylation in Multiple Sclerosis: Beyond DNA.Myeloid leukemia with transdifferentiation plasticity developing from T-cell progenitors.SRPK1 inhibition in prostate cancer: A novel anti-angiogenic treatment through modulation of VEGF alternative splicing.The mitochondrial translation machinery as a therapeutic target in Myc-driven lymphomasThe spliceosome, a potential Achilles heel of MYC-driven tumorsIntegrative analysis of RNA polymerase II and transcriptional dynamics upon MYC activation.The role of alternative splicing in cancer.c-Myc deregulation induces mRNA capping enzyme dependency.Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation.
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P2860
MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
MYC regulates the core pre-mRN ...... ntial step in lymphomagenesis.
@en
type
label
MYC regulates the core pre-mRN ...... ntial step in lymphomagenesis.
@en
prefLabel
MYC regulates the core pre-mRN ...... ntial step in lymphomagenesis.
@en
P2093
P2860
P50
P356
P1433
P1476
MYC regulates the core pre-mRN ...... ntial step in lymphomagenesis.
@en
P2093
Cheryl M Koh
Diana H P Low
Ernesto Guccione
Florence P H Gay
Keng Boon Wee
Marco Bezzi
Motomi Osato
Muthafar Al-Haddawi
Shun Xie Teo
Wei Xia Ang
P2860
P2888
P304
P356
10.1038/NATURE14351
P407
P577
2015-05-11T00:00:00Z
P6179
1020478940