The multi-functional cellular adhesion molecule CD44 is regulated by the 8;21 chromosomal translocation.
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t(8;21)(q22;q22) Fusion proteins preferentially bind to duplicated AML1/RUNX1 DNA-binding sequences to differentially regulate gene expression.Variable selection for discriminant analysis with Markov random field priors for the analysis of microarray dataCD44 ligation with A3D8 antibody induces apoptosis in acute myeloid leukemia cells through binding to CD44s and clustering lipid rafts.Cooperation between RUNX1-ETO9a and novel transcriptional partner KLF6 in upregulation of Alox5 in acute myeloid leukemia.Thrombopoietin/MPL participates in initiating and maintaining RUNX1-ETO acute myeloid leukemia via PI3K/AKT signaling.Combined gene expression and DNA occupancy profiling identifies potential therapeutic targets of t(8;21) AML.Applications of microarray technology to Acute Myelogenous LeukemiaRUNX1-ETO induces a type I interferon response which negatively effects t(8;21)-induced increased self-renewal and leukemia development.JAK inhibitors suppress t(8;21) fusion protein-induced leukemia.CD44 in hematological neoplasias.AML1/ETO accelerates cell migration and impairs cell-to-cell adhesion and homing of hematopoietic stem/progenitor cells.Functional polymorphisms in the CD44 gene and acute myeloid leukemia cancer risk in a Chinese population.Recurrent Mutations in the MTOR Regulator RRAGC in Follicular Lymphoma.RUNX1/ETO blocks selectin-mediated adhesion via epigenetic silencing of PSGL-1.Role of CD44 as a marker of cancer stem cells in head and neck cancer.The truncated RUNX1/ETO activates VLA-4-dependent adhesion and migration of hematopoietic progenitor cells.Distinct mechanisms of regulation of the ITGA6 and ITGB4 genes by RUNX1 in myeloid cells.Targeting Leukemia Stem Cells in the Bone Marrow Niche.Aberrant expression of CD19 in AML with t(8;21) involves a poised chromatin structure and PAX5.
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P2860
The multi-functional cellular adhesion molecule CD44 is regulated by the 8;21 chromosomal translocation.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
The multi-functional cellular ...... ;21 chromosomal translocation.
@en
type
label
The multi-functional cellular ...... ;21 chromosomal translocation.
@en
prefLabel
The multi-functional cellular ...... ;21 chromosomal translocation.
@en
P2093
P2860
P356
P1433
P1476
The multi-functional cellular ...... ;21 chromosomal translocation.
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.LEU.2404849
P577
2007-07-26T00:00:00Z
P5875
P6179
1050358903