The homeobox protein Six3 interacts with the Groucho corepressor and acts as a transcriptional repressor in eye and forebrain formation.
about
Mutations in the human SIX3 gene in holoprosencephaly are loss of functionSix3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain developmentGbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressorsRepression of Six3 by a corepressor regulates rhodopsin expressionTranscriptional regulation of cranial sensory placode developmentExpression of Groucho/TLE proteins during pancreas developmentMutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype.Absence of chx10 causes neural progenitors to persist in the adult retinaSix3 activation of Pax6 expression is essential for mammalian lens induction and specificationMeis homeoproteins directly regulate Pax6 during vertebrate lens morphogenesisAntagonistic effects of Grg6 and Groucho/TLE on the transcription repression activity of brain factor 1/FoxG1 and cortical neuron differentiation.Using Xenopus to discover new genes involved in branchiootorenal spectrum disordersThe sine oculis homeobox (SIX) family of transcription factors as regulators of development and diseaseBalancing cell numbers during organogenesis: Six1a differentially affects neurons and sensory hair cells in the inner ear.Nitro-fatty acids and cyclopentenone prostaglandins share strategies to activate the Keap1-Nrf2 system: a study using green fluorescent protein transgenic zebrafishTemporal and epigenetic regulation of neurodevelopmental plasticity.Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis.The Drosophila Wilms׳ Tumor 1-Associating Protein (WTAP) homolog is required for eye development.Conservation and diversification of an ancestral chordate gene regulatory network for dorsoventral patterningTissue-restricted expression of Nrf2 and its target genes in zebrafish with gene-specific variations in the induction profiles.A role for cell cycle-regulated phosphorylation in Groucho-mediated transcriptional repression.AES/GRG5: more than just a dominant-negative TLE/GRG family memberFly SIX-type homeodomain proteins Sine oculis and Optix partner with different cofactors during eye development.Embryonic origin of the eyes in teleost fish.The Eye Specification Network in DrosophilaOntogenesis of peptidergic neurons within the genoarchitectonic map of the mouse hypothalamus.The visual system of zebrafish and its use to model human ocular diseases.Functional dissection of eyes absent reveals new modes of regulation within the retinal determination gene network.Inhibition of cortical neuron differentiation by Groucho/TLE1 requires interaction with WRPW, but not Eh1, repressor peptides.Dual transcriptional activities of SIX proteins define their roles in normal and ectopic eye developmentInduction and specification of the vertebrate ectodermal placodes: precursors of the cranial sensory organs.Expression of Barhl2 and its relationship with Pax6 expression in the forebrain of the mouse embryo.LSD1/KDM1A promotes hematopoietic commitment of hemangioblasts through downregulation of Etv2.Genetic evidence of an evolutionarily conserved role for Nrf2 in the protection against oxidative stress.Clinical spectrum of SIX3-associated mutations in holoprosencephaly: correlation between genotype, phenotype and functionSelf-association of Gata1 enhances transcriptional activity in vivo in zebra fish embryosThe molecular circuitry governing retinal determination.Novel dominant-negative mutation within the six domain of the conserved eye specification gene sine oculis inhibits eye development in Drosophila.Eye evolution: common use and independent recruitment of genetic components.Position dependent responses to discontinuities in the retinal determination network.
P2860
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P2860
The homeobox protein Six3 interacts with the Groucho corepressor and acts as a transcriptional repressor in eye and forebrain formation.
description
2001 nĆ® lÅ«n-bĆ»n
@nan
2001幓ć®č«ę
@ja
2001幓č«ę
@yue
2001幓č«ę
@zh-hant
2001幓č«ę
@zh-hk
2001幓č«ę
@zh-mo
2001幓č«ę
@zh-tw
2001幓č®ŗę
@wuu
2001幓č®ŗę
@zh
2001幓č®ŗę
@zh-cn
name
The homeobox protein Six3 inte ...... n eye and forebrain formation.
@en
type
label
The homeobox protein Six3 inte ...... n eye and forebrain formation.
@en
prefLabel
The homeobox protein Six3 inte ...... n eye and forebrain formation.
@en
P2093
P356
P1476
The homeobox protein Six3 inte ...... n eye and forebrain formation.
@en
P2093
Kobayashi M
Nishikawa K
Yamamoto M
P304
P356
10.1006/DBIO.2001.0185
P407
P577
2001-04-01T00:00:00Z