Activation and functional characterization of the mosaic receptor SorLA/LR11.
about
SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1Rho kinase II phosphorylation of the lipoprotein receptor LR11/SORLA alters amyloid-beta productionGGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β productionCharacterization of sorCS1, an alternatively spliced receptor with completely different cytoplasmic domains that mediate different trafficking in cellsLipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's diseaseRisk factor SORL1: from genetic association to functional validation in Alzheimer's diseaseThe sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA bindingSortilin as a regulator of lipoprotein metabolismInteraction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartmentsLoss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's diseaseTargeted delivery of brain-derived neurotrophic factor for the treatment of blindness and deafness.Diverse roles of neurotensin agonists in the central nervous systemFunctional organization of the sortilin Vps10p domain.SorCS3 does not require propeptide cleavage to bind nerve growth factor.Stabilin-1 localizes to endosomes and the trans-Golgi network in human macrophages and interacts with GGA adaptors.A membrane proximal helix in the cytosolic domain of the human APP interacting protein LR11/SorLA deforms liposomes.Bacterial expression, purification, and model membrane reconstitution of the transmembrane and cytoplasmic domains of the human APP binding protein LR11/SorLA for NMR studies.Modulation of beta-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family.The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review.Sorting protein-related receptor SorLA controls regulated secretion of glial cell line-derived neurotrophic factor.Multi-tasking by the p75 neurotrophin receptor: sortilin things out?Neurotensin agonists as an alternative to antipsychotics.Mapping of the interaction site between sortilin and the p75 neurotrophin receptor reveals a regulatory role for the sortilin intracellular domain in p75 neurotrophin receptor shedding and apoptosisThe role of neurotensin in central nervous system pathophysiology: what is the evidence?Vps10 family proteins and the retromer complex in aging-related neurodegeneration and diabetes.Structural and functional analysis of APOA5 mutations identified in patients with severe hypertriglyceridemia.LR11/SorLA expression is reduced in sporadic Alzheimer disease but not in familial Alzheimer disease.Neuronal LR11/sorLA expression is reduced in mild cognitive impairmentAssociation of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer diseaseSORL1 mutations in early- and late-onset Alzheimer disease.Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain.Amyloid precursor protein processing and Alzheimer's diseaseThe role of lipoprotein receptors on the physiological function of APP.Sortilin and SorLA regulate neuronal sorting of trophic and dementia-linked proteins.N-linked oligosaccharides on the low density lipoprotein receptor homolog SorLA/LR11 are modified with terminal GalNAc-4-SO4 in kidney and brain.SorLA complement-type repeat domains protect the amyloid precursor protein against processing.Sorting receptor SORLA: cellular mechanisms and implications for disease.Binding Sites for Amyloid-β Oligomers and Synaptic Toxicity.Sortilin facilitates signaling of ciliary neurotrophic factor and related helical type 1 cytokines targeting the gp130/leukemia inhibitory factor receptor beta heterodimer.
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P2860
Activation and functional characterization of the mosaic receptor SorLA/LR11.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Activation and functional characterization of the mosaic receptor SorLA/LR11.
@en
type
label
Activation and functional characterization of the mosaic receptor SorLA/LR11.
@en
prefLabel
Activation and functional characterization of the mosaic receptor SorLA/LR11.
@en
P2093
P2860
P921
P356
P1476
Activation and functional characterization of the mosaic receptor SorLA/LR11
@en
P2093
Gliemann J
Jacobsen C
Jacobsen L
Petersen CM
P2860
P304
22788-22796
P356
10.1074/JBC.M100857200
P407
P577
2001-04-09T00:00:00Z