The mechanism of DNA cytosine-5 methylation. Kinetic and mutational dissection of Hhai methyltransferase.
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Probing a rate-limiting step by mutational perturbation of AdoMet binding in the HhaI methyltransferaseDNA bending by M.EcoKI methyltransferase is coupled to nucleotide flipping.Time-resolved fluorescence of 2-aminopurine as a probe of base flipping in M.HhaI-DNA complexesMechanisms of superoxide signaling in epigenetic processes: relation to aging and cancerStructures of liganded and unliganded RsrI N6-adenine DNA methyltransferase: a distinct orientation for active cofactor bindingStudy of bacteriophage T4-encoded Dam DNA (adenine-N6)-methyltransferase binding with substrates by rapid laser UV cross-linking.Metadynamics simulation study on the conformational transformation of HhaI methyltransferase: an induced-fit base-flipping hypothesisControl of catalytic cycle by a pair of analogous tRNA modification enzymes.A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status.Protein-facilitated base flipping in DNA by cytosine-5-methyltransferase.Beyond Watson and Crick: DNA methylation and molecular enzymology of DNA methyltransferases.Hyperthermophilic DNA methyltransferase M.PabI from the archaeon Pyrococcus abyssiDNA methylation is developmentally regulated for genes essential for cardiogenesis.Transducing methyltransferase activity into electrical signals in a carbon nanotube-DNA device().Approaches for studying microRNA and small interfering RNA methylation in vitro and in vivo.DNA cytosine methylation: structural and thermodynamic characterization of the epigenetic marking mechanism.Dimeric/oligomeric DNA methyltransferases: an unfinished story.New nucleophilic mechanisms of ros-dependent epigenetic modifications: comparison of aging and cancer.DNA methyltransferases: mechanistic models derived from kinetic analysis.Molecular modeling of inhibitors of human DNA methyltransferase with a crystal structure: discovery of a novel DNMT1 inhibitor.DNA methyltransferase inhibitors in acute myeloid leukemia: discovery, design and first therapeutic experiences.Causes and Consequences of Age-Related Changes in DNA Methylation: A Role for ROS?Water-assisted dual mode cofactor recognition by HhaI DNA methyltransferase.Bacteriophage T4 Dam DNA-[N6-adenine]methyltransferase. Kinetic evidence for a catalytically essential conformational change in the ternary complex.Nucleotide flipping by restriction enzymes analyzed by 2-aminopurine steady-state fluorescence.Mutational analysis of conserved residues in HhaI DNA methyltransferaseSubstrate specificity and kinetic mechanism of mammalian G9a histone H3 methyltransferase.Preferential methylation of unmethylated DNA by Mammalian de novo DNA methyltransferase Dnmt3a.The structure of the TrmE GTP-binding protein and its implications for tRNA modification.Mechanism of N-methylation by the tRNA m1G37 methyltransferase Trm5.A directed evolution design of a GCG-specific DNA hemimethylase.Direct observation of cytosine flipping and covalent catalysis in a DNA methyltransferase.Molecular characterization of Ancylostoma inhibitors of coagulation factor Xa. Hookworm anticoagulant activity in vitro predicts parasite bloodfeeding in vivo.Dye label interference with RNA modification reveals 5-fluorouridine as non-covalent inhibitor.The coupling of tight DNA binding and base flipping: identification of a conserved structural motif in base flipping enzymes.Characterization of gamma-tocopherol methyltransferases from Capsicum annuum L and Arabidopsis thaliana.Bacteriophage T4 Dam DNA-(N6-adenine)-methyltransferase. Processivity and orientation to the methylation target.Kinetic and catalytic properties of dimeric KpnI DNA methyltransferase.DNA (cytosine-N4-)- and -(adenine-N6-)-methyltransferases have different kinetic mechanisms but the same reaction route. A comparison of M.BamHI and T4 Dam.MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.
P2860
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P2860
The mechanism of DNA cytosine-5 methylation. Kinetic and mutational dissection of Hhai methyltransferase.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
The mechanism of DNA cytosine- ...... ion of Hhai methyltransferase.
@en
type
label
The mechanism of DNA cytosine- ...... ion of Hhai methyltransferase.
@en
prefLabel
The mechanism of DNA cytosine- ...... ion of Hhai methyltransferase.
@en
P2093
P2860
P356
P1476
The mechanism of DNA cytosine- ...... ion of Hhai methyltransferase.
@en
P2093
Klimasauskas S
Merkiene E
Vilkaitis G
Weinhold E
P2860
P304
20924-20934
P356
10.1074/JBC.M101429200
P407
P577
2001-03-29T00:00:00Z