A functional GTP-binding motif is necessary for antiviral activity of Mx proteins.
about
Interferon-induced antiviral protein MxA interacts with the cellular RNA helicases UAP56 and URH49Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infectionResistance to virus infection conferred by the interferon-induced promyelocytic leukemia proteinThe helical domain of GBP-1 mediates the inhibition of endothelial cell proliferation by inflammatory cytokines.Antiviral actions of interferonsDominant-negative mutants of human MxA protein: domains in the carboxy-terminal moiety are important for oligomerization and antiviral activityHuman MxA protein confers resistance to Semliki Forest virus and inhibits the amplification of a Semliki Forest virus-based replicon in the absence of viral structural proteinsRegulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondiiInfluenza A virus strains differ in sensitivity to the antiviral action of Mx-GTPaseThe nucleoprotein of newly emerged H7N9 influenza A virus harbors a unique motif conferring resistance to antiviral human MxA.The viral nucleoprotein determines Mx sensitivity of influenza A viruses.Interferon-inducible protein Mx1 inhibits influenza virus by interfering with functional viral ribonucleoprotein complex assemblyPandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoprotein.An assembly-incompetent mutant establishes a requirement for dynamin self-assembly in clathrin-mediated endocytosis in vivo.The cytoplasmic location of chicken mx is not the determining factor for its lack of antiviral activityAntivirally active MxA protein sequesters La Crosse virus nucleocapsid protein into perinuclear complexes.Transfer of the amino-terminal nuclear envelope targeting domain of human MX2 converts MX1 into an HIV-1 resistance factorGenetic variation within the Mx gene of commercially selected chicken lines reveals multiple haplotypes, recombination and a protein under selection pressure.Partial antiviral activities detection of chicken Mx jointing with neuraminidase gene (NA) against Newcastle disease virusRole of nucleotide binding and GTPase domain dimerization in dynamin-like myxovirus resistance protein A for GTPase activation and antiviral activity.Mx1 and Mx2 key antiviral proteins are surprisingly lost in toothed whalesThe immunity-related GTPases in mammals: a fast-evolving cell-autonomous resistance system against intracellular pathogens.Oligomerization Requirements for MX2-Mediated Suppression of HIV-1 InfectionEvolution-guided identification of antiviral specificity determinants in the broadly acting interferon-induced innate immunity factor MxA.Host genetics of severe influenza: from mouse Mx1 to human IRF7Antiviral determinants of rat Mx GTPases map to the carboxy-terminal half.Mx proteins: antiviral gatekeepers that restrain the uninvited.Lentiviral vectors encoding short hairpin RNAs efficiently transduce and knockdown LINGO-1 but induce an interferon response and cytotoxicity in central nervous system neurones.Oligomerization and GTP-binding Requirements of MxA for Viral Target Recognition and Antiviral Activity against Influenza A Virus.Polymorphisms and the differential antiviral activity of the chicken Mx gene.Asparagine 631 variants of the chicken Mx protein do not inhibit influenza virus replication in primary chicken embryo fibroblasts or in vitro surrogate assays.Cell type-specific MxA-mediated inhibition of measles virus transcription in human brain cells.A systematic analysis of the RNA-targeting potential of secreted bacterial effector proteins.Chemical-controlled Activation of Antiviral Myxovirus Resistance Protein 1.Functional Comparison of Mx1 from Two Different Mouse Species Reveals the Involvement of Loop L4 in the Antiviral Activity against Influenza A Viruses.MxA Mediates SUMO-Induced Resistance to Vesicular Stomatitis Virus.Chemotactic Activity of Cyclophilin A in the Skin Mucus of Yellow Catfish (Pelteobagrus fulvidraco) and Its Active Site for Chemotaxis.Mx is dispensable for interferon-mediated resistance of chicken cells against influenza A virus.The GTPase activity of murine guanylate-binding protein 2 (mGBP2) controls the intracellular localization and recruitment to the parasitophorous vacuole of Toxoplasma gondii.Porcine Mx1 protein inhibits classical swine fever virus replication by targeting nonstructural protein NS5B.
P2860
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P2860
A functional GTP-binding motif is necessary for antiviral activity of Mx proteins.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
A functional GTP-binding motif is necessary for antiviral activity of Mx proteins.
@en
type
label
A functional GTP-binding motif is necessary for antiviral activity of Mx proteins.
@en
prefLabel
A functional GTP-binding motif is necessary for antiviral activity of Mx proteins.
@en
P2093
P2860
P1433
P1476
A functional GTP-binding motif is necessary for antiviral activity of Mx proteins.
@en
P2093
Pavlovic J
Schröder A
Schwemmle M
Staeheli P
P2860
P304
P407
P577
1993-11-01T00:00:00Z