Enhancement of streptolysin O activity and intrinsic cytotoxic effects of the group A streptococcal toxin, NAD-glycohydrolase.
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Structure and Function of an ADP-Ribose-Dependent Transcriptional Regulator of NAD MetabolismHigh-resolution crystal structure of Streptococcus pyogenes β-NAD + glycohydrolase in complex with its endogenous inhibitor IFS reveals a highly water-rich interfaceNADase as a target molecule of in vivo suppression of the toxicity in the invasive M-1 group A Streptococcal isolates.Characterization of Streptococcus pyogenes beta-NAD+ glycohydrolase: re-evaluation of enzymatic properties associated with pathogenesis.Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences.Inhibition of Inflammasome-Dependent Interleukin 1β Production by Streptococcal NAD+-Glycohydrolase: Evidence for Extracellular Activity.Variation in Streptococcus pyogenes NAD+ glycohydrolase is associated with tissue tropism.Signal transduction through CsrRS confers an invasive phenotype in group A Streptococcus.M protein and hyaluronic acid capsule are essential for in vivo selection of covRS mutations characteristic of invasive serotype M1T1 group A Streptococcus.Streptolysin O and NAD-glycohydrolase prevent phagolysosome acidification and promote group A Streptococcus survival in macrophages.Streptolysin O inhibits clathrin-dependent internalization of group A StreptococcusStreptolysin O and its co-toxin NAD-glycohydrolase protect group A Streptococcus from Xenophagic killing.NAD+-Glycohydrolase Promotes Intracellular Survival of Group A Streptococcus.The Streptococcus pyogenes NAD(+) glycohydrolase modulates epithelial cell PARylation and HMGB1 releaseThe NADase-Negative Variant of the Streptococcus pyogenes Toxin NAD⁺ Glycohydrolase Induces JNK1-Mediated Programmed Cellular Necrosis.Autophagy in innate immunity against intracellular bacteria.The signal recognition particle pathway is required for virulence in Streptococcus pyogenesHow group A Streptococcus circumvents host phagocyte defenses.Analysis of polymorphic residues reveals distinct enzymatic and cytotoxic activities of the Streptococcus pyogenes NAD+ glycohydrolase.Streptolysin O promotes group A Streptococcus immune evasion by accelerated macrophage apoptosis.Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-kappa B activation but proceeds independently of TLR signaling and P2X7 receptor.Streptococcal toxins: role in pathogenesis and disease.Exploring NAD+ metabolism in host-pathogen interactions.Lactobacilli reduce cell cytotoxicity caused by Streptococcus pyogenes by producing lactic acid that degrades the toxic component lipoteichoic acid.Streptococcus pyogenes serotype-dependent and independent changes in infected HEp-2 epithelial cells.Binding of NAD+-Glycohydrolase to Streptolysin O Stabilizes Both Toxins and Promotes Virulence of Group A Streptococcus.Contribution of Secreted NADase and Streptolysin O to the Pathogenesis of Epidemic Serotype M1 Streptococcus pyogenes Infections.PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain.NAD-Glycohydrolase Depletes Intracellular NAD and Inhibits Acidification of Autophagosomes to Enhance Multiplication of Group A in Endothelial Cells
P2860
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P2860
Enhancement of streptolysin O activity and intrinsic cytotoxic effects of the group A streptococcal toxin, NAD-glycohydrolase.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Enhancement of streptolysin O ...... cal toxin, NAD-glycohydrolase.
@en
type
label
Enhancement of streptolysin O ...... cal toxin, NAD-glycohydrolase.
@en
prefLabel
Enhancement of streptolysin O ...... cal toxin, NAD-glycohydrolase.
@en
P2093
P2860
P356
P1476
Enhancement of streptolysin O ...... cal toxin, NAD-glycohydrolase.
@en
P2093
Amit Srivastava
Efi Kokkotou
Ioannis Gryllos
Michael R Wessels
P2860
P304
P356
10.1074/JBC.M511674200
P407
P577
2006-01-23T00:00:00Z