Pit-1 binding sites at the somatotrope-specific DNase I hypersensitive sites I, II of the human growth hormone locus control region are essential for in vivo hGH-N gene activation.
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Functional characterization of a human POU1F1 mutation associated with isolated growth hormone deficiency: a novel etiology for IGHDA PIT-1 homeodomain mutant blocks the intranuclear recruitment of the CCAAT/enhancer binding protein alpha required for prolactin gene transcriptionIkaros integrates endocrine and immune system developmentAn essential role for the hematopoietic transcription factor Ikaros in hypothalamic-pituitary-mediated somatic growth.Epigenetic characterization of the growth hormone gene identifies SmcHD1 as a regulator of autosomal gene clusters.The human growth hormone locus control region mediates long-distance transcriptional activation independent of nuclear matrix attachment regionsSpecification of unique Pit-1 activity in the hGH locus control region.Research resource: T-antigen transformation of pituitary cells captures three novel cell lines in the Pit-1 lineage.Lentiviral and Moloney retroviral expression of green fluorescent protein in somatotrophs in vivo.Patterns of histone acetylation suggest dual pathways for gene activation by a bifunctional locus control region.The role of the hGH locus control region in somatotrope restriction of hGH-N gene expression.A single base difference between Pit-1 binding sites at the hGH promoter and locus control region specifies distinct Pit-1 conformations and functionsAutonomous actions of the human growth hormone long-range enhancerAn RNA-independent linkage of noncoding transcription to long-range enhancer function.Differential epigenetic and transcriptional response of the skeletal muscle carnitine palmitoyltransferase 1B (CPT1B) gene to lipid exposure with obesityDNase I hypersensitive site II of the human growth hormone locus control region mediates an essential and distinct long-range enhancer functionEpigenetic activation of the human growth hormone gene cluster during placental cytotrophoblast differentiation.B29 gene silencing in pituitary cells is regulated by its 3' enhancerGrowth hormone deficiency and combined pituitary hormone deficiency: does the genotype matter?Distinct chromatin configurations regulate the initiation and the maintenance of hGH gene expressionThe juxtaposition of a promoter with a locus control region transcriptional domain activates gene expression.Molecular physiology of pituitary development: signaling and transcriptional networks.Identification of a secondary promoter within the human B cell receptor component gene hCD79bLong-range looping of a locus control region drives tissue-specific chromatin packing within a multigene clusterAppearance of the pituitary factor Pit-1 increases chromatin remodeling at hypersensitive site III in the human GH locus.Bystander gene activation by a locus control region.Tissue specific CTCF occupancy and boundary function at the human growth hormone locus.Adipokines (Leptin, Adiponectin, Resistin) Differentially Regulate All Hormonal Cell Types in Primary Anterior Pituitary Cell Cultures from Two Primate SpeciesEvidence for a Circadian Effect on the Reduction of Human Growth Hormone Gene Expression in Response to Excess Caloric IntakeChromatin status and transcription factor binding to gonadotropin promoters in gonadotrope cell lines.A member of the nuclear factor-1 family is involved in the pituitary repression of the human placental growth hormone genes.
P2860
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P2860
Pit-1 binding sites at the somatotrope-specific DNase I hypersensitive sites I, II of the human growth hormone locus control region are essential for in vivo hGH-N gene activation.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Pit-1 binding sites at the som ...... in vivo hGH-N gene activation.
@en
type
label
Pit-1 binding sites at the som ...... in vivo hGH-N gene activation.
@en
prefLabel
Pit-1 binding sites at the som ...... in vivo hGH-N gene activation.
@en
P2093
P2860
P356
P1476
Pit-1 binding sites at the som ...... in vivo hGH-N gene activation
@en
P2093
B M Shewchuk
S A Liebhaber
P2860
P304
35725-35733
P356
10.1074/JBC.274.50.35725
P407
P577
1999-12-01T00:00:00Z