Activation of the unfolded protein response pathway induces human asparagine synthetase gene expression.
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ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase geneDistinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein responseTranslation mediated by the internal ribosome entry site of the cat-1 mRNA is regulated by glucose availability in a PERK kinase-dependent mannerNck-dependent activation of extracellular signal-regulated kinase-1 and regulation of cell survival during endoplasmic reticulum stress.Nonsense-mediated RNA decay regulation by cellular stress: implications for tumorigenesis.Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis.Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element.Asparagine synthetase: regulation by cell stress and involvement in tumor biologyUpregulation of the coagulation factor VII gene during glucose deprivation is mediated by activating transcription factor 4.Functional analysis of a novel DNA polymorphism of a tandem repeated sequence in the asparagine synthetase gene in acute lymphoblastic leukemia cells.Endoplasmic Reticulum Stress and Autophagy in Homocystinuria Patients with Remethylation Defects.Alignment of the transcription start site coincides with increased transcriptional activity from the human asparagine synthetase gene following amino acid deprivation of HepG2 cells.Transcriptional induction of the human asparagine synthetase gene during the unfolded protein response does not require the ATF6 and IRE1/XBP1 arms of the pathwayResetting translational homeostasis restores myelination in Charcot-Marie-Tooth disease type 1B miceDeletion of Scap in alveolar type II cells influences lung lipid homeostasis and identifies a compensatory role for pulmonary lipofibroblasts.Mouse models of cystathionine beta-synthase deficiency reveal significant threshold effects of hyperhomocysteinemia.An extracellular bacterial pathogen modulates host metabolism to regulate its own sensing and proliferation.CCAAT/enhancer-binding protein-beta is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene.Targeting cancer cell metabolism in pancreatic adenocarcinoma.Metabolic crosstalk between host and pathogen: sensing, adapting and competing.CCAAT/enhancer-binding protein-beta participates in insulin-responsive expression of the factor VII gene.Human CCAAT/enhancer-binding protein beta gene expression is activated by endoplasmic reticulum stress through an unfolded protein response element downstream of the protein coding sequence.Characterization of the nutrient-sensing response unit in the human asparagine synthetase promoter.Differences in the molecular mechanisms involved in the transcriptional activation of the CHOP and asparagine synthetase genes in response to amino acid deprivation or activation of the unfolded protein response.Amino acid deprivation and endoplasmic reticulum stress induce expression of multiple activating transcription factor-3 mRNA species that, when overexpressed in HepG2 cells, modulate transcription by the human asparagine synthetase promoter.Upregulation of asparagine synthetase fails to avert cell cycle arrest induced by L-asparaginase in TEL/AML1-positive leukaemic cells.ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma.Genetic interaction between the ero1-1 and leu2 mutations in Saccharomyces cerevisiae.Characterization of a novel variant in siblings with Asparagine Synthetase Deficiency.Amino Acids As Mediators of Metabolic Cross Talk between Host and Pathogen.
P2860
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P2860
Activation of the unfolded protein response pathway induces human asparagine synthetase gene expression.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Activation of the unfolded pro ...... ne synthetase gene expression.
@en
type
label
Activation of the unfolded pro ...... ne synthetase gene expression.
@en
prefLabel
Activation of the unfolded pro ...... ne synthetase gene expression.
@en
P2093
P2860
P356
P1476
Activation of the unfolded pro ...... ne synthetase gene expression.
@en
P2093
Barbosa-Tessmann IP
Kilberg MS
Schuster SM
P2860
P304
31139-31144
P356
10.1074/JBC.274.44.31139
P407
P577
1999-10-01T00:00:00Z