Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT.

Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT.

Item

http://www.wikidata.org/entity/Q38319485

Q38319485

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The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin Down-regulation of ubiquitin ligase Cbl induced by twist haploinsufficiency in Saethre-Chotzen syndrome results in increased PI3K/Akt signaling and osteoblast proliferation Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2 Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation Overlapping functions of nuclear envelope proteins NET25 (Lem2) and emerin in regulation of extracellular signal-regulated kinase signaling in myoblast differentiation T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling WNT5A is a regulator of fibroblast proliferation and resistance to apoptosis Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells The Role of Bone Marrow Microenvironment in Governing the Balance between Osteoblastogenesis and Adipogenesis Targeting the Wnt pathways for therapies Control of bone mass and remodeling by PTH receptor signaling in osteocytes Distinct transcriptional networks in quiescent myoblasts: a role for Wnt signaling in reversible vs. irreversible arrest Myricetin induces apoptosis by inhibiting P21 activated kinase 1 (PAK1) signaling cascade in hepatocellular carcinoma From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis The estrogen receptor-alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone Delineation of in vitro chondrogenesis of human synovial stem cells following preconditioning using decellularized matrix A switch from canonical to noncanonical Wnt signaling mediates drug resistance in colon cancer cells Transforming growth factor-beta prevents osteoblast apoptosis induced by skeletal unloading via PI3K/Akt, Bcl-2, and phospho-Bad signaling Control of bone formation by the serpentine receptor Frizzled-9 Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia Wingless ligand 5a is a critical regulator of placental growth and survival Wnt10b deficiency results in age-dependent loss of bone mass and progressive reduction of mesenchymal progenitor cells Identification of genes regulated by Wnt/beta-catenin pathway and involved in apoptosis via microarray analysis.Akt1 in osteoblasts and osteoclasts controls bone remodeling.FK506 can activate transforming growth factor-beta signalling in vascular smooth muscle cells and promote proliferation.N-cadherin negatively regulates osteoblast proliferation and survival by antagonizing Wnt, ERK and PI3K/Akt signalling.Cdh11 acts as a tumor suppressor in a murine retinoblastoma model by facilitating tumor cell death.Hepatocyte growth factor (Hgf) stimulates low density lipoprotein receptor-related protein (Lrp) 5/6 phosphorylation and promotes canonical Wnt signaling Wnt signaling and osteoporosis.Update in new anabolic therapies for osteoporosis Expression patterns and action analysis of genes associated with hepatitis virus infection during rat liver regeneration.Intermittent parathyroid hormone administration counteracts the adverse effects of glucocorticoids on osteoblast and osteocyte viability, bone formation, and strength in mice.Gene expression profiles induced by growth factors in in vitro cultured osteoblasts.T cells: critical bone regulators in health and disease.Functional coupling between the extracellular matrix and nuclear lamina by Wnt signaling in progeria.The immune system and bone.Decreased oxidative stress and greater bone anabolism in the aged, when compared to the young, murine skeleton with parathyroid hormone administration.Complex expression pattern of Wnt ligands and frizzled receptors in human placenta and its trophoblast subtypes.

P2860

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P2860

Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT.

Item

http://www.wikidata.org/entity/Q38319485

description

2005 nî lūn-bûn

@nan

2005年の論文

@ja

2005年学术文章

@wuu

2005年学术文章

@zh-cn

2005年学术文章

@zh-hans

2005年学术文章

@zh-my

2005年学术文章

@zh-sg

2005年學術文章

@yue

2005年學術文章

@zh

2005年學術文章

@zh-hant

name

Wnt proteins prevent apoptosis ...... phatidylinositol 3-kinase/AKT.

@en

type

Item

label

Wnt proteins prevent apoptosis ...... phatidylinositol 3-kinase/AKT.

@en

prefLabel

Wnt proteins prevent apoptosis ...... phatidylinositol 3-kinase/AKT.

@en

P1476

Wnt proteins prevent apoptosis ...... phatidylinositol 3-kinase/AKT.

@en

P2093

Li Han

http://www.w3.org/2001/XMLSchema#string

Maria Almeida

http://www.w3.org/2001/XMLSchema#string

Stavros C Manolagas

http://www.w3.org/2001/XMLSchema#string

Stavroula Kousteni

http://www.w3.org/2001/XMLSchema#string

P2860

Functional analysis of H-Ryk, an atypical member of the receptor tyrosine kinase family

Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling

Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors

Identification of c-MYC as a target of the APC pathway

Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling.

A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

P304

41342-41351

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P31

scholarly article

P356

10.1074/JBC.M502168200

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P407

English

P433

http://www.w3.org/2001/XMLSchema#string

P478

280

http://www.w3.org/2001/XMLSchema#string

P50

Teresita M. Bellido

P577

2005-10-25T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

16251184

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P921

osteoblast

Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT.

about

P2860

P2860

Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT.

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P921

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P921