about
Mechanism of the Escherichia coli ADP-ribose pyrophosphatase, a Nudix hydrolaseStructure of the extracellular region of HER2 alone and in complex with the Herceptin FabStructure of a Coenzyme A Pyrophosphatase from Deinococcus radiodurans: a Member of the Nudix FamilyStructure and mechanism of MT-ADPRase, a nudix hydrolase from Mycobacterium tuberculosisStructure and function of the E. coli dihydroneopterin triphosphate pyrophosphatase: a Nudix enzyme involved in folate biosynthesisThe structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutationsDevelopment of Broad-Spectrum Halomethyl Ketone Inhibitors Against Coronavirus Main Protease 3CLproStructure and Biological Function of the RNA Pyrophosphohydrolase BdRppH from Bdellovibrio bacteriovorusA frequent kinase domain mutation that changes the interaction between PI3K and the membraneBinding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimerMutation of Asn28 Disrupts the Dimerization and Enzymatic Activity of SARS 3CL proStructural Insights into Maize Viviparous14, a Key Enzyme in the Biosynthesis of the Phytohormone Abscisic AcidStructural studies of the Nudix GDP-mannose hydrolase from E. coli reveals a new motif for mannose recognitionThe Nudix Hydrolase CDP-Chase, a CDP-Choline Pyrophosphatase, Is an Asymmetric Dimer with Two Distinct Enzymatic ActivitiesPyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1 in CellsA UDP-X Diphosphatase from Streptococcus pneumoniae Hydrolyzes Precursors of Peptidoglycan BiosynthesisDesign, Synthesis, Calorimetry, and Crystallographic Analysis of 2-Alkylaminoethyl-1,1-bisphosphonates as Inhibitors of Trypanosoma cruzi Farnesyl Diphosphate SynthaseStructural and thermodynamic basis of the inhibition ofLeishmania majorfarnesyl diphosphate synthase by nitrogen-containing bisphosphonatesKinetic and mutational studies of the adenosine diphosphate ribose hydrolase from Mycobacterium tuberculosisStructure and activity of the axon guidance protein MICALStructures and mechanisms of Nudix hydrolases.X-ray, NMR, and mutational studies of the catalytic cycle of the GDP-mannose mannosyl hydrolase reaction.C-terminal recognition by 14-3-3 proteins for surface expression of membrane receptors.Somatic mutations in PI3Kalpha: structural basis for enzyme activation and drug designNHE3 activity is dependent on direct phosphoinositide binding at the N terminus of its intracellular cytosolic region.Salting out of proteins using ammonium sulfate precipitation.Using ion exchange chromatography to purify a recombinantly expressed protein.Regulation of the NaV1.5 cytoplasmic domain by calmodulinA redox regulatory system critical for mycobacterial survival in macrophages and biofilm development.Generation of MANAbodies specific to HLA-restricted epitopes encoded by somatically mutated genes.Structural and Enzymatic Characterization of a Nucleoside Diphosphate Sugar Hydrolase from Bdellovibrio bacteriovorusOncogenic mutations weaken the interactions that stabilize the p110α-p85α heterodimer in phosphatidylinositol 3-kinase α.Identification of allosteric binding sites for PI3Kα oncogenic mutant specific inhibitor design.Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis.Structural comparisons of class I phosphoinositide 3-kinases.Capitalizing on tumor genotyping: towards the design of mutation specific inhibitors of phosphoinsitide-3-kinase.Activation of PI3Kα by physiological effectors and by oncogenic mutations: structural and dynamic effects.Calmodulin and Ca(2+) control of voltage gated Na(+) channels.Phosphorylation of NHE3-S719 regulates NHE3 activity through the formation of multiple signaling complexes.
P50
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P50
description
hulumtuese
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Sandra B. Gabelli
@ast
Sandra B. Gabelli
@en
Sandra B. Gabelli
@es
Sandra B. Gabelli
@nl
Sandra B. Gabelli
@sl
type
label
Sandra B. Gabelli
@ast
Sandra B. Gabelli
@en
Sandra B. Gabelli
@es
Sandra B. Gabelli
@nl
Sandra B. Gabelli
@sl
prefLabel
Sandra B. Gabelli
@ast
Sandra B. Gabelli
@en
Sandra B. Gabelli
@es
Sandra B. Gabelli
@nl
Sandra B. Gabelli
@sl
P1053
A-3705-2008
P106
P1153
6602684057
P21
P31
P3829
P496
0000-0003-1205-5204