Selective up-regulation of fatty acid uptake by adipocytes characterizes both genetic and diet-induced obesity in rodents.
about
Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesityChronic leptin administration decreases fatty acid uptake and fatty acid transporters in rat skeletal muscleRole of insulin and free fatty acids in the regulation of ob gene expression and plasma leptin in normal rats.Regulatable fatty acid transport mechanisms are central to the pathophysiology of obesity, fatty liver, and metabolic syndrome.Adipocyte accumulation of long-chain fatty acids in obesity is multifactorial, resulting from increased fatty acid uptake and decreased activity of genes involved in fat utilization.Insulin- and leptin-regulated fatty acid uptake plays a key causal role in hepatic steatosis in mice with intact leptin signaling but not in ob/ob or db/db mice.Mfge8 promotes obesity by mediating the uptake of dietary fats and serum fatty acids.Leptin and the adipocyte endocrine system.Transmembrane movement of exogenous long-chain fatty acids: proteins, enzymes, and vectorial esterification.In silico models for dynamic connected cell cultures mimicking hepatocyte-endothelial cell-adipocyte interaction circleCardiomyocyte triglyceride accumulation and reduced ventricular function in mice with obesity reflect increased long chain Fatty Acid uptake and de novo Fatty Acid synthesis.Lipid metabolism and liver inflammation. I. Hepatic fatty acid uptake: possible role in steatosis.Facilitated long chain fatty acid uptake by adipocytes remains upregulated relative to BMI for more than a year after major bariatric surgical weight loss.Is membrane transport of FFA mediated by lipid, protein, or both? Mechanisms and regulation of protein-mediated cellular fatty acid uptake: molecular, biochemical, and physiological evidence.Nonalcoholic Fatty Liver Disease: Lipids and Insulin Resistance.Chronic ethanol consumption increases cardiomyocyte fatty acid uptake and decreases ventricular contractile function in C57BL/6J miceMolecular modeling and functional confirmation of a predicted fatty acid binding site of mitochondrial aspartate aminotransferase.Fatty acid transport in Saccharomyces cerevisiae. Directed mutagenesis of FAT1 distinguishes the biochemical activities associated with Fat1p.Changes in fatty acid transport and transporters are related to the severity of insulin deficiency.Insulin stimulates fatty acid transport by regulating expression of FAT/CD36 but not FABPpm.Differences in adipocyte long chain fatty acid uptake in Osborne-Mendel and S5B/Pl rats in response to high-fat diets.Long-chain fatty acid uptake is upregulated in omental adipocytes from patients undergoing bariatric surgery for obesity.
P2860
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P2860
Selective up-regulation of fatty acid uptake by adipocytes characterizes both genetic and diet-induced obesity in rodents.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Selective up-regulation of fat ...... et-induced obesity in rodents.
@en
type
label
Selective up-regulation of fat ...... et-induced obesity in rodents.
@en
prefLabel
Selective up-regulation of fat ...... et-induced obesity in rodents.
@en
P2093
P2860
P356
P1476
Selective up-regulation of fat ...... iet-induced obesity in rodents
@en
P2093
P2860
P304
28626-28631
P356
10.1074/JBC.274.40.28626
P407
P50
P577
1999-10-01T00:00:00Z