about
Dasatinib inhibits CXCR4 signaling in chronic lymphocytic leukaemia cells and impairs migration towards CXCL12Regulation of thymocyte differentiation: pre-TCR signals and beta-selection.Nfix expression critically modulates early B lymphopoiesis and myelopoiesisThe link between PKCalpha regulation and cellular transformation.Evidence that hematopoietic stem cell function is preserved during aging in long-lived S6K1 mutant mice.CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells.Elucidating the role of protein kinase C in chronic lymphocytic leukaemia.Murine models for chronic lymphocytic leukaemia.Death-associated protein kinase (DAPK) and signal transduction: regulation in cancer.CML cells actively evade host immune surveillance through cytokine-mediated downregulation of MHC-II expression.Protein kinase C in cellular transformation: a valid target for therapy?Modulation of PKC-α promotes lineage reprogramming of committed B lymphocytes.Dasatinib inhibits B cell receptor signalling in chronic lymphocytic leukaemia but novel combination approaches are required to overcome additional pro-survival microenvironmental signals.Uptake of synthetic Low Density Lipoprotein by leukemic stem cells--a potential stem cell targeted drug delivery strategy.Alternative splicing of the type-IVA cyclic AMP phosphodiesterase gene provides isoform variants with distinct N-terminal domains fused to a common, soluble catalytic unit: 'designer' changes in Vmax, stability and membrane association.Cyclic adenosine 5'-monophosphate response element binding protein plays a central role in mediating proliferation and differentiation downstream of the pre-TCR complex in developing thymocytes.Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation.Extracellular signal-regulated kinase (ERK) activation by the pre-T cell receptor in developing thymocytes in vivo.The characteristics, capacity and receptor regulation of inositol uptake in 1321N1 astrocytoma cells.In vivo detection of intracellular signaling pathways in developing thymocytes.Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T cell antigen receptor on thymocytes: analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram.Generation of a poor prognostic chronic lymphocytic leukemia-like disease model: PKCα subversion induces up-regulation of PKCβII expression in B lymphocytes.Determining the role of specific signaling molecules during lymphocyte development in vivo: instant transgenesis.Immune complex-mediated co-ligation of the BCR with FcγRIIB results in homeostatic apoptosis of B cells involving Fas signalling that is defective in the MRL/Lpr model of systemic lupus erythematosus.Chromatin looping defines expression of TAL1, its flanking genes, and regulation in T-ALL.Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells.The role of mTOR-mediated signaling in the regulation of cellular migration.Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals.Transfection and transcription of genes in developing thymocytes.Natural killer cell development and function precede alpha beta T cell differentiation in mouse fetal thymic ontogeny.Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes prosurvival stimuli to induce apoptosis in chronic lymphocytic leukemia cells.Subversion of protein kinase C alpha signaling in hematopoietic progenitor cells results in the generation of a B-cell chronic lymphocytic leukemia-like population in vivo.Upregulation of cAMP-specific PDE-4 activity following ligation of the TCR complex on thymocytes is blocked by selective inhibitors of protein kinase C and tyrosyl kinasesThe role of mTOR-mediated signals during haemopoiesis and lineage commitmentComplement deficiencies limit CD20 monoclonal antibody treatment efficacy in CLLMegakaryocytes assemble podosomes that degrade matrix and protrude through basement membraneNotch is constitutively active in Theileria-transformed B cells and can be further stimulated by the filarial nematode-secreted product, ES-62Duration and Strength of Extracellular Signal-Regulated Kinase Signals Are Altered During Positive Versus Negative Thymocyte SelectionClonal Characterization of a Bipotent T Cell and NK Cell Progenitor in the Mouse Fetal ThymusEarly intrathymic precursor cells acquire a CD4(low) phenotype
P50
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P50
description
hulumtuese
@sq
researcher
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wetenschapper
@nl
հետազոտող
@hy
name
Alison M Michie
@ast
Alison M Michie
@en
Alison M Michie
@es
Alison M Michie
@fr
Alison M Michie
@nl
Alison M Michie
@sl
type
label
Alison M Michie
@ast
Alison M Michie
@en
Alison M Michie
@es
Alison M Michie
@fr
Alison M Michie
@nl
Alison M Michie
@sl
prefLabel
Alison M Michie
@ast
Alison M Michie
@en
Alison M Michie
@es
Alison M Michie
@fr
Alison M Michie
@nl
Alison M Michie
@sl
P106
P21
P31
P496
0000-0002-5404-475X