about
Cell-type-specific epigenetic marking of the IL2 gene at a distal cis-regulatory region in competent, nontranscribing T-cellsRegulatory gene network circuits underlying T cell development from multipotent progenitorsMast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3A far downstream enhancer for murine Bcl11b controls its T-cell specific expressionCell-type-specific activation and repression of PU.1 by a complex of discrete, functionally specialized cis-regulatory elementsA gene regulatory network armature for T lymphocyte specification.Transcriptional establishment of cell-type identity: dynamics and causal mechanisms of T-cell lineage commitment.Expression and function of a stem cell promoter for the murine CBFalpha2 gene: distinct roles and regulation in natural killer and T cell development.Asynchronous combinatorial action of four regulatory factors activates Bcl11b for T cell commitmentBcl11b and combinatorial resolution of cell fate in the T-cell gene regulatory network.Lineage divergence at the first TCR-dependent checkpoint: preferential γδ and impaired αβ T cell development in nonobese diabetic mice.Fine-scale staging of T cell lineage commitment in adult mouse thymus.Stepwise specification of lymphocyte developmental lineages.Progression of regulatory gene expression states in fetal and adult pro-T-cell development.GATA-3 dose-dependent checkpoints in early T cell commitment.Elements of transcription factor network design for T-lineage specification.Lineage plasticity and commitment in T-cell development.T-lineage specification and commitment: a gene regulation perspective.Notch/Delta signaling constrains reengineering of pro-T cells by PU.1.Regulatory coding of lymphoid lineage choice by hematopoietic transcription factors.Regulation of early T-lineage gene expression and developmental progression by the progenitor cell transcription factor PU.1.Origins of lymphocyte developmental programs: transcription factor evidence.Molecular genetics of T cell development.Irreversibility of T-Cell Specification: Insights from Computational Modelling of a Minimal Network Architecture.Developmental biologist Eric H. Davidson, 1937-2015Immune Cell Identity: Perspective from a PalimpsestArchitecture of a lymphomyeloid developmental switch controlled by PU.1, Notch and Gata3.GATA-3 locks the door to the B-cell option.Loss of T cell progenitor checkpoint control underlies leukemia initiation in Rag1-deficient nonobese diabetic mice.Core binding factors are necessary for natural killer cell development and cooperate with Notch signaling during T-cell specificationEric Davidson: Steps to a gene regulatory network for development.Cell lineage regulators in B and T cell development.Regulatory factors for initial T lymphocyte lineage specification.Negotiation of the T lineage fate decision by transcription-factor interplay and microenvironmental signals.Launching the T-cell-lineage developmental programmeCompetition and collaboration: GATA-3, PU.1, and Notch signaling in early T-cell fate determination.Molecular mechanisms that control mouse and human TCR-alphabeta and TCR-gammadelta T cell development.Positive feedback between PU.1 and the cell cycle controls myeloid differentiationMultilayered specification of the T-cell lineage fate.T cell lineage commitment: identity and renunciation.
P50
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P50
description
hulumtuese
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onderzoeker
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researcher
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հետազոտող
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name
Ellen V. Rothenberg
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Ellen V. Rothenberg
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Ellen V. Rothenberg
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Ellen V. Rothenberg
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type
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Ellen V. Rothenberg
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Ellen V. Rothenberg
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Ellen V. Rothenberg
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Ellen V. Rothenberg
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Ellen V. Rothenberg
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Ellen V. Rothenberg
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Ellen V. Rothenberg
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Ellen V. Rothenberg
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Ellen V. Rothenberg
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P106
P1153
7005964351
P21
P31
P496
0000-0002-3901-347X