Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes.
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Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteomeThe Aryl Hydrocarbon Receptor Relays Metabolic Signals to Promote Cellular RegenerationCommon mechanisms involved in Alzheimer's disease and type 2 diabetes: a key role of chronic bacterial infection and inflammationMetabolomics applied to the pancreatic isletMetabolic syndrome and renal cell carcinomaIdentifying novel transcriptional components controlling energy metabolismTranscriptional and epigenetic regulation in human isletsIntronic cis-regulatory modules mediate tissue-specific and microbial control of angptl4/fiaf transcriptionInsulin-receptor substrate-2 (irs-2) is required for maintaining glucokinase and glucokinase regulatory protein expression in mouse liverNCOA5 haploinsufficiency results in glucose intolerance and subsequent hepatocellular carcinomaHypoxia-inducible factor-1alpha regulates beta cell function in mouse and human isletsGlucose-induced O₂ consumption activates hypoxia inducible factors 1 and 2 in rat insulin-secreting pancreatic beta-cellsEvaluating diabetes and hypertension disease causality using mouse phenotypesEarly degenerative effects of diabetes mellitus on pancreas, liver, and kidney in rats: an immunohistochemical study.Genomic and genotoxic responses to controlled weathered-oil exposures confirm and extend field studies on impacts of the Deepwater Horizon oil spill on native killifish.Detecting multivariate differentially expressed genes.Islet specific Wnt activation in human type II diabetes.Algorithmic approach for removing the redundancy in diabetic gene categories based on semantic similarity and gene expression data.Is dynamic autocrine insulin signaling possible? A mathematical model predicts picomolar concentrations of extracellular monomeric insulin within human pancreatic islets.Aryl hydrocarbon receptor nuclear translocator (ARNT) gene as a positional and functional candidate for type 2 diabetes and prediabetic intermediate traits: Mutation detection, case-control studies, and gene expression analysis.Meta-analysis approach identifies candidate genes and associated molecular networks for type-2 diabetes mellitus.Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitusCarbohydrate-responsive element-binding protein (ChREBP) is a negative regulator of ARNT/HIF-1beta gene expression in pancreatic islet beta-cells.An islet in distress: β cell failure in type 2 diabetes.Increases in insulin sensitivity among obese youth are associated with gene expression changes in whole blood.Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketonesβ-Cell failure in type 2 diabetes.Type 2 diabetes susceptibility gene expression in normal or diabetic sorted human alpha and beta cells: correlations with age or BMI of islet donors.A map of open chromatin in human pancreatic islets.Oxygen tension regulates pancreatic beta-cell differentiation through hypoxia-inducible factor 1alpha.Polymorphic cis- and trans-regulation of human gene expression.Gene regulatory network reveals oxidative stress as the underlying molecular mechanism of type 2 diabetes and hypertension.Automated assessment of β-cell area and density per islet and patient using TMEM27 and BACE2 immunofluorescence staining in human pancreatic β-cells.Insulin enhances glucose-stimulated insulin secretion in healthy humansIncreased ectodomain shedding of cell adhesion molecule 1 from pancreatic islets in type 2 diabetic pancreata: correlation with hemoglobin A1c levels.Meta-analysis of heterogeneous data sources for genome-scale identification of risk genes in complex phenotypes.HIF-prolyl hydroxylases as therapeutic targets in erythropoiesis and iron metabolismThe asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolismGene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes.Clusters of conserved beta cell marker genes for assessment of beta cell phenotype.
P2860
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P2860
Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Loss of ARNT/HIF1beta mediates ...... tion in human type 2 diabetes.
@en
type
label
Loss of ARNT/HIF1beta mediates ...... tion in human type 2 diabetes.
@en
prefLabel
Loss of ARNT/HIF1beta mediates ...... tion in human type 2 diabetes.
@en
P2093
P50
P1433
P1476
Loss of ARNT/HIF1beta mediates ...... tion in human type 2 diabetes.
@en
P2093
Frank J Gonzalez
Jenny E Gunton
Philip J O'Connell
Rohit N Kulkarni
Russell S Roberson
SunHee Yim
Terumasa Okada
Wayne J Hawthorne
P304
P356
10.1016/J.CELL.2005.05.027
P407
P577
2005-08-01T00:00:00Z