Molecular basis for developmental changes in interleukin-2 gene inducibility.
about
NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymusRORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cellsCell-type-specific epigenetic marking of the IL2 gene at a distal cis-regulatory region in competent, nontranscribing T-cellsNFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificitySequences between the enhancer and promoter in the long terminal repeat affect murine leukemia virus pathogenicity and replication in the thymus.When immunization leads to autoimmunity: chronic inflammation as a result of thymic and mucosal dysregulation in IL-2 knock-out mice.Progression of regulatory gene expression states in fetal and adult pro-T-cell development.Transcriptional control of invariant NKT cell development.Evidence for the Role of Cyclic AMP-Responsive Elements in Human Virus Replication and Disease.Chromatin remodeling complex NURF regulates thymocyte maturation.An essential role for nuclear factor kappaB in promoting double positive thymocyte apoptosis.Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.Gene transcription in differentiating immature T cell receptor(neg) thymocytes resembles antigen-activated mature T cells.Positive and negative regulation of the composite octamer motif of the interleukin 2 enhancer by AP-1, Oct-2, and retinoic acid receptor.Nuclear factors that mediate intrathymic signals are developmentally regulated.Induction of the early growth response (Egr) family of transcription factors during thymic selection.Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-kappaB.At the crossroads: diverse roles of early thymocyte transcriptional regulators.Regulation of AP-1 and NFAT transcription factors during thymic selection of T cells.Interleukin-2 transcription is regulated in vivo at the level of coordinated binding of both constitutive and regulated factors.A dynamic assembly of diverse transcription factors integrates activation and cell-type information for interleukin 2 gene regulation.Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signals.AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes.Novel NFAT sites that mediate activation of the interleukin-2 promoter in response to T-cell receptor stimulationForging T-Lymphocyte Identity: Intersecting Networks of Transcriptional Control.A regulatory element in the human interleukin 2 gene promoter is a binding site for the zinc finger proteins Sp1 and EGR-1.Chromatin remodeling of the interleukin-2 gene: distinct alterations in the proximal versus distal enhancer regions.Transcription mediated by NFAT is highly inducible in effector CD4+ T helper 2 (Th2) cells but not in Th1 cells.Signal transduction, mitotic catastrophes, and death in T-cell development.Modulation of endoplasmic reticulum calcium pump expression during T lymphocyte activation.Early T-cell development in CD3-deficient mice.Interleukin 2 transcription factors as molecular targets of cAMP inhibition: delayed inhibition kinetics and combinatorial transcription roles.Specific regulation of fos family transcription factors in thymocytes at two developmental checkpoints.Costimulation by interleukin-1 of multiple activation responses in a developmentally restricted subset of immature thymocytes.Direct manipulation of activator protein-1 controls thymocyte proliferation in vitro.A dominant-negative mutant of c-Jun inhibits cell cycle progression during the transition of CD4(-)CD8(-) to CD4(+)CD8(+) thymocytes.
P2860
Q24316786-C597E68D-1382-45FC-938E-DD0104913065Q24657337-E1189769-059A-418D-A4A0-B654C1AE0191Q24810248-5B80D9EF-FAFD-43AF-8A8E-15CABDB2926FQ28591436-CD8AE49D-86E8-44ED-8E3B-70EDAF5C73F7Q33814017-395746BE-DAEA-4D94-8027-02DD213BDDBBQ33836359-6CE56575-3B51-4846-9B2F-38B454721C86Q34150401-42C49796-C9B9-4756-BFE5-02F2ED2671C1Q34248566-AF5C9D56-4BB4-4517-A0B1-91320D543FF7Q34450059-314DCB0A-03E8-4725-A4AE-E76CF8BD8070Q34557161-E534A796-EA58-497C-881B-6C331F0CCC46Q35834615-122D9778-58CF-4BD3-BFAC-6E6ED8FFD14AQ35924279-9231C749-3E6D-4772-8562-512CFA60A71CQ36362403-7F55B106-8681-45A7-B362-D66BF9187CECQ36363848-68A9F8E6-609E-4462-B1BD-2C0631F0DD5CQ36364085-D6E1A0EF-DF87-4AC6-821B-385921DEA36EQ36376794-525EC3D7-BBF9-4FDB-A29E-4E19612B0F65Q36377290-D75AB823-4904-4C3E-AD06-754812AD2EA0Q36382771-80C21CF0-2899-41FA-BA6E-D2F764798061Q36557490-F40B6645-FE7C-4C9E-A7D1-94C3FBF699D2Q36648966-43B818AD-5F17-4DC9-8F8B-08777B77D1FDQ37349310-CC1EF0E2-4527-4A49-A886-BED41EFB132FQ37415532-143AD755-7FFA-45C1-B7A1-3F880A784A2FQ37636349-50B8296B-83AA-4294-BF19-A3753CE421EFQ38289894-82C83142-D32D-4A11-B79C-3D5FE86FB48FQ38320682-A43CD81A-5B36-4B67-9B02-07A2AC5C3EA9Q39469566-3C228711-F19D-427F-A61B-7324C177B7D4Q39724268-05AFA9A9-DA49-4F64-8850-2F3CA615B313Q40021175-526AE3C9-FA76-461F-B548-99023676E74FQ40495457-E40568CD-864B-4DCC-876A-D2D9B1EA30DBQ41115431-6DD97B06-DF19-4FEF-917F-3505F96D41F2Q41126128-29D8885C-0455-4392-973E-CDFE0CFFF2B4Q41483826-168E95A7-B00A-46DE-9575-737425FF0931Q41665482-8FBBD6B1-5133-4AB3-9CDC-1DB412EDB5A2Q45931446-0C5178A5-00B8-4F66-839E-0E8579F45D19Q46870562-0FB8DA79-9262-4ECD-9DE6-C90456B36B99Q52175566-88EF4615-0F21-42BD-86B3-86A08D4FE803
P2860
Molecular basis for developmental changes in interleukin-2 gene inducibility.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh
1993年學術文章
@zh-hant
name
Molecular basis for developmental changes in interleukin-2 gene inducibility.
@en
type
label
Molecular basis for developmental changes in interleukin-2 gene inducibility.
@en
prefLabel
Molecular basis for developmental changes in interleukin-2 gene inducibility.
@en
P2860
P356
P1476
Molecular basis for developmental changes in interleukin-2 gene inducibility.
@en
P2093
E V Rothenberg
P2860
P304
P356
10.1128/MCB.13.1.228
P407
P577
1993-01-01T00:00:00Z