Methylation analysis of CGG sites in the CpG island of the human FMR1 gene.
about
Purification of nuclear proteins from human HeLa cells that bind specifically to the unstable tandem repeat (CGG)n in the human FMR1 geneCpG island methylator phenotype in colorectal cancerFragile X (CGG)n repeats induce a transcriptional repression in cis upon a linked promoter: evidence for a chromatin mediated effectNutrition, epigenetics, and metabolic syndromeThe fragile X gene and its functionActivation of the lac repressor in the transgenic mouse.Gene expression profiling of lymphoblastoid cell lines from monozygotic twins discordant in severity of autism reveals differential regulation of neurologically relevant genes.Molecular and cellular genetics of fragile X syndrome.Interruption of the fragile X syndrome expanded sequence d(CGG)(n) by interspersed d(AGG) trinucleotides diminishes the formation and stability of d(CGG)(n) tetrahelical structuresEvidence for RNA-mediated toxicity in the fragile X-associated tremor/ataxia syndrome.Rapid antibody test for prenatal diagnosis of fragile X syndrome on amniotic fluid cells: a new appraisalUnusual mutations in high functioning fragile X males: apparent instability of expanded unmethylated CGG repeats.X inactivation of the FMR1 fragile X mental retardation geneMethylation mosaicism of 5'-(CGG)(n)-3' repeats in fragile X, premutation and normal individuals.Biology of the fragile X mental retardation protein, an RNA-binding protein.Stability of the human fragile X (CGG)(n) triplet repeat array in Saccharomyces cerevisiae deficient in aspects of DNA metabolism.Hypomethylation of an expanded FMR1 allele is not associated with a global DNA methylation defect.FMRP detection assay for the diagnosis of the fragile X syndrome.Expanded CTG repeat demarcates a boundary for abnormal CpG methylation in myotonic dystrophy patient tissuesRapid protein sequencing by tandem mass spectrometry and cDNA cloning of p20-CGGBP. A novel protein that binds to the unstable triplet repeat 5'-d(CGG)n-3' in the human FMR1 gene.Cloned human FMR1 trinucleotide repeats exhibit a length- and orientation-dependent instability suggestive of in vivo lagging strand secondary structure.An antisense transcript spanning the CGG repeat region of FMR1 is upregulated in premutation carriers but silenced in full mutation individuals.Methylation of slipped duplexes, snapbacks and cruciforms by human DNA(cytosine-5)methyltransferase.Gender-specific effect of Mthfr genotype and neonatal vigabatrin interaction on synaptic proteins in mouse cortexHairpin-bisulfite PCR: assessing epigenetic methylation patterns on complementary strands of individual DNA molecules.Evidence that methylation of the FMR-I locus is responsible for variable phenotypic expression of the fragile X syndrome.Characterization of FMR1 promoter elements by in vivo-footprinting analysis.The fragile X syndrome d(CGG)n nucleotide repeats form a stable tetrahelical structure.Increase of FMRP expression, raised levels of FMR1 mRNA, and clonal selection in proliferating cells with unmethylated fragile X repeat expansions: a clue to the sex bias in the transmission of full mutations?Instability of the CGG repeat and expression of the FMR1 protein in a male fragile X patient with a lung tumor.Quantitative comparison of FMR1 gene expression in normal and premutation allelesTwo new cases of FMR1 deletion associated with mental impairment.Genomic imprinting: mechanism and role in human pathology.Triplet repeat expansion at the FRAXE locus and X-linked mild mental handicap.A multicenter study on genotype-phenotype correlations in the fragile X syndrome, using direct diagnosis with probe StB12.3: the first 2,253 cases.A variable domain of delayed replication in FRAXA fragile X chromosomes: X inactivation-like spread of late replicationTrinucleotide repeats and neuropsychiatric disorders.Reciprocal changes in DNA methylation and hydroxymethylation and a broad repressive epigenetic switch characterize FMR1 transcriptional silencing in fragile X syndromeCarcinogenic nickel silences gene expression by chromatin condensation and DNA methylation: a new model for epigenetic carcinogens.Clinical genetics in neurological disease.
P2860
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P2860
Methylation analysis of CGG sites in the CpG island of the human FMR1 gene.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年学术文章
@wuu
1992年学术文章
@zh-cn
1992年学术文章
@zh-hans
1992年学术文章
@zh-my
1992年学术文章
@zh-sg
1992年學術文章
@yue
1992年學術文章
@zh
1992年學術文章
@zh-hant
name
Methylation analysis of CGG sites in the CpG island of the human FMR1 gene.
@en
type
label
Methylation analysis of CGG sites in the CpG island of the human FMR1 gene.
@en
prefLabel
Methylation analysis of CGG sites in the CpG island of the human FMR1 gene.
@en
P2093
P356
P1476
Methylation analysis of CGG sites in the CpG island of the human FMR1 gene.
@en
P2093
P304
P356
10.1093/HMG/1.8.571
P577
1992-11-01T00:00:00Z