Inhibitory autophosphorylation of multifunctional Ca2+/calmodulin-dependent protein kinase analyzed by site-directed mutagenesis.
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Calcium input frequency, duration and amplitude differentially modulate the relative activation of calcineurin and CaMKIIAutophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin bindingStructure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activationRequirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma.Optical induction of plasticity at single synapses reveals input-specific accumulation of alphaCaMKIIIdentification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganizationMechanisms of CaMKII action in long-term potentiationA Mechanism for Tunable Autoinhibition in the Structure of a Human Ca2+/Calmodulin- Dependent Kinase II HoloenzymePKC- and ERK-dependent activation of I kappa B kinase by lipopolysaccharide in macrophages: enhancement by P2Y receptor-mediated CaMK activationCalcium-calmodulin signalling pathway up-regulates glutamatergic synaptic function in non-pyramidal, fast spiking rat hippocampal CA1 neuronsImproving a natural CaMKII inhibitor by random and rational designFast Decay of CaMKII FRET Sensor Signal in Spines after LTP Induction Is Not Due to Its Dephosphorylation.Calmodulin mediates differential sensitivity of CaMKII and calcineurin to local Ca2+ in cardiac myocytesDifferential functional properties of calmodulin-dependent protein kinase IIgamma variants isolated from smooth muscle.Regulation of excitation-contraction coupling in mouse cardiac myocytes: integrative analysis with mathematical modellingCaMKII autonomy is substrate-dependent and further stimulated by Ca2+/calmodulin.Nitric oxide induces Ca2+-independent activity of the Ca2+/calmodulin-dependent protein kinase II (CaMKII).Autonomous CaMKII requires further stimulation by Ca2+/calmodulin for enhancing synaptic strengthA mechanism for synaptic frequency detection through autophosphorylation of CaM kinase II.A significant but rather mild contribution of T286 autophosphorylation to Ca2+/CaM-stimulated CaMKII activity.CaMKII activation and dynamics are independent of the holoenzyme structure: an infinite subunit holoenzyme approximationStructure-function of the multifunctional Ca2+/calmodulin-dependent protein kinase II.Metabolic control of Ca2+/calmodulin-dependent protein kinase II (CaMKII)-mediated caspase-2 suppression by the B55β/protein phosphatase 2A (PP2A)Conformational changes underlying calcium/calmodulin-dependent protein kinase II activation.CaMKII binding to GluN2B is differentially affected by macromolecular crowding reagents.Nucleotides and phosphorylation bi-directionally modulate Ca2+/calmodulin-dependent protein kinase II (CaMKII) binding to the N-methyl-D-aspartate (NMDA) receptor subunit GluN2B.Covert Changes in CaMKII Holoenzyme Structure Identified for Activation and Subsequent Interactions.Targeting of calcium/calmodulin-dependent protein kinase II.Emergence of clonal hematopoiesis in the majority of patients with acquired aplastic anemia.Differential expression of CaMKII isoforms and overall kinase activity in rat dorsal root ganglia after injury.Wip1 phosphatase modulates both long-term potentiation and long-term depression through the dephosphorylation of CaMKIIRibosylation triggering Alzheimer's disease-like Tau hyperphosphorylation via activation of CaMKII.Alternative splicing introduces a nuclear localization signal that targets multifunctional CaM kinase to the nucleus.CaMKII regulation in information processing and storage.The delicate bistability of CaMKIICa(2+)/calmodulin-dependent protein kinases.Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase IISmooth muscle signalling pathways in health and disease.CaMKII-induced shift in modal gating explains L-type Ca(2+) current facilitation: a modeling study.Regulation of intrasteric inhibition of the multifunctional calcium/calmodulin-dependent protein kinase.
P2860
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P2860
Inhibitory autophosphorylation of multifunctional Ca2+/calmodulin-dependent protein kinase analyzed by site-directed mutagenesis.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年学术文章
@wuu
1992年学术文章
@zh-cn
1992年学术文章
@zh-hans
1992年学术文章
@zh-my
1992年学术文章
@zh-sg
1992年學術文章
@yue
1992年學術文章
@zh
1992年學術文章
@zh-hant
name
Inhibitory autophosphorylation ...... by site-directed mutagenesis.
@en
type
label
Inhibitory autophosphorylation ...... by site-directed mutagenesis.
@en
prefLabel
Inhibitory autophosphorylation ...... by site-directed mutagenesis.
@en
P1476
Inhibitory autophosphorylation ...... by site-directed mutagenesis.
@en
P2093
P304
17216-17224
P407
P577
1992-08-01T00:00:00Z