A scintillation proximity assay for the Raf/MEK/ERK kinase cascade: high-throughput screening and identification of selective enzyme inhibitors.
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Role of sorafenib in the treatment of advanced hepatocellular carcinoma: An updateCTA095, a novel Etk and Src dual inhibitor, induces apoptosis in prostate cancer cells and overcomes resistance to Src inhibitorsPhosphatase-coupled universal kinase assay and kinetics for first-order-rate coupling reactionTargeting Btk/Etk of prostate cancer cells by a novel dual inhibitorData concordance from a comparison between filter binding and fluorescence polarization assay formats for identification of ROCK-II inhibitors.Molecular characteristics of CTA056, a novel interleukin-2-inducible T-cell kinase inhibitor that selectively targets malignant T cells and modulates oncomirs.Development of anticancer drugs targeting the MAP kinase pathway.Scintillation proximity assay in lead discovery.Discovery of potent, orally active compounds of tyrosine kinase and serine/threonine-protein kinase inhibitor with anti-tumor activity in preclinical assays.Measuring the tyrosine kinase activity: a review of biochemical and cellular assay technologies.The preclinical development of regorafenib for the treatment of colorectal cancer.Sorafenib enriches epithelial cell adhesion molecule-positive tumor initiating cells and exacerbates a subtype of hepatocellular carcinoma through TSC2-AKT cascade.Identification of inhibitors of the kinase activity of oncogenic V600E BRAF in an enzyme cascade high-throughput screen.Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A down regulates c-myc gene expression and endothelial cell proliferation.Comparison of the biochemical and kinetic properties of the type 1 receptor tyrosine kinase intracellular domains. Demonstration of differential sensitivity to kinase inhibitors.Expressed in the yeast Saccharomyces cerevisiae, human ERK5 is a client of the Hsp90 chaperone that complements loss of the Slt2p (Mpk1p) cell integrity stress-activated protein kinaseFluorescent cascade and direct assays for characterization of RAF signaling pathway inhibitors.A cGMP-dependent protein kinase assay for high throughput screening based on time-resolved fluorescence resonance energy transfer.Use of red-shifted dyes in a fluorescence polarization AKT kinase assay for detection of biological activity in natural product extracts.In vitro enzymatic assays for Ser/Thr-selective protein kinases.
P2860
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P2860
A scintillation proximity assay for the Raf/MEK/ERK kinase cascade: high-throughput screening and identification of selective enzyme inhibitors.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
A scintillation proximity assa ...... f selective enzyme inhibitors.
@en
type
label
A scintillation proximity assa ...... f selective enzyme inhibitors.
@en
prefLabel
A scintillation proximity assa ...... f selective enzyme inhibitors.
@en
P2093
P356
P1476
A scintillation proximity assa ...... f selective enzyme inhibitors.
@en
P2093
C J Marshall
O B McDonald
P304
P356
10.1006/ABIO.1998.3030
P407
P577
1999-03-01T00:00:00Z