DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA. - Wikidata - wikimedia - TriplyDB

DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA.

DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA.

http://www.wikidata.org/entity/Q38331301

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Inhibition of DNA-dependent protein kinase catalytic subunit by small molecule inhibitor NU7026 sensitizes human leukemic K562 cells to benzene metabolite-induced apoptosis Kinetic mechanism of AKT/PKB enzyme family DNA-dependent protein kinase catalytic subunit (DNA-PKcs)-SIN1 association mediates ultraviolet B (UVB)-induced Akt Ser-473 phosphorylation and skin cell survival Extreme-longevity mutations orchestrate silencing of multiple signaling pathways Cellular stress response and innate immune signaling: integrating pathways in host defense and inflammation.RNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis during DNA damage Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment DNA-PK target identification reveals novel links between DNA repair signaling and cytoskeletal regulation The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation.Bacterial DNA Protects Monocytic Cells against HIV-Vpr-Induced Mitochondrial Membrane Depolarization.Phosphoinositide 3-kinaseγ controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages TCR-induced Akt serine 473 phosphorylation is regulated by protein kinase C-alpha Wogonin induced calreticulin/annexin A1 exposure dictates the immunogenicity of cancer cells in a PERK/AKT dependent manner.Involvement of DNA-PKcs in the IL-6 and IL-12 response to CpG-ODN is mediated by its interaction with TRAF6 in dendritic cells.Involvement of DNA-PKcs in the type I IFN response to CpG-ODNs in conventional dendritic cells in TLR9-dependent or -independent manners.Stimulation of Proliferation and Migration of Mouse Macrophages by Type B CpG-ODNs Is F-Spondin and IL-1Ra Dependent.CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells.A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA.High basal STAT4 balanced by STAT1 induction to control type 1 interferon effects in natural killer cells.TLR9 in health and disease.Protein phosphatase 2A and DNA-dependent protein kinase are involved in mediating rapamycin-induced Akt phosphorylation.Priming with EGFR tyrosine kinase inhibitor and EGF sensitizes ovarian cancer cells to respond to chemotherapeutical drugs.FANCI is a negative regulator of Akt activation.KU-0060648 inhibits hepatocellular carcinoma cells through DNA-PKcs-dependent and DNA-PKcs-independent mechanisms.Over-expression of DNA-PKcs in renal cell carcinoma regulates mTORC2 activation, HIF-2α expression and cell proliferation.Differential effects of the CpG-Toll-like receptor 9 axis on pregnancy outcome in nonobese diabetic mice and wild-type controls.Deregulation of DNA-dependent protein kinase catalytic subunit contributes to human hepatocarcinogenesis development and has a putative prognostic value.TLR9 activation coupled to IL-10 deficiency induces adverse pregnancy outcomes.G(i)α proteins exhibit functional differences in the activation of ERK1/2, Akt and mTORC1 by growth factors in normal and breast cancer cells.IFN-α production by human mononuclear cells infected with varicella-zoster virus through TLR9-dependent and -independent pathways.Radiosensitizing activity of a novel Benzoxazine through the promotion of apoptosis and inhibition of DNA repair.Baicalein (5,6,7-trihydroxyflavone) reduces oxidative stress-induced DNA damage by upregulating the DNA repair system.Extreme Depletion of PIP3 Accompanies the Increased Life Span and Stress Tolerance of PI3K-null C. elegans Mutants.TRAIL is involved in CpG ODN-mediated anti-apoptotic signals CpG-induced tyrosine phosphorylation occurs via a TLR9-independent mechanism and is required for cytokine secretion.DNA-dependent protein kinase-mediated phosphorylation of protein kinase B requires a specific recognition sequence in the C-terminal hydrophobic motif.DNA-dependent protein kinase is involved in heat shock protein-mediated accumulation of hypoxia-inducible factor-1alpha in hypoxic preconditioned HepG2 cells.Activation of toll-like receptor-9 induces matrix metalloproteinase-9 expression through Akt and tumor necrosis factor-alpha signaling.DNA-PKcs controls calcineurin mediated IL-2 production in T lymphocytes.In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis.

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P2860

DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA.

http://www.wikidata.org/entity/Q38331301

description

2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年學術文章

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2005年學術文章

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2005年學術文章

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name

DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA.

@en

type

label

DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA.

@en

prefLabel

DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA.

@en

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SJ.EMBOJ.7600539

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The EMBO Journal

P1476

DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA.

@en

P2093

Ana-Maria Dragoi

http://www.w3.org/2001/XMLSchema#string

Dianqing Wu

http://www.w3.org/2001/XMLSchema#string

Gloria C Li

http://www.w3.org/2001/XMLSchema#string

Linbo Sheng

http://www.w3.org/2001/XMLSchema#string

Ping Zhang

http://www.w3.org/2001/XMLSchema#string

Stanimir Ivanov

http://www.w3.org/2001/XMLSchema#string

Wen-Ming Chu

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Xiaoying Fu

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P2860

A Toll-like receptor recognizes bacterial DNA

A DNA-activated protein kinase from HeLa cell nuclei

Tcl1 enhances Akt kinase activity and mediates its nuclear translocation

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

The protooncogene TCL1 is an Akt kinase coactivator

Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

The DNA-dependent protein kinase

Role of translocation in the activation and function of protein kinase B

Cellular survival: a play in three Akts

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4

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24

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8054205

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15678105

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Toll-like receptor

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549614

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