Molecular basis for substrate specificity of protein-tyrosine phosphatase 1B.
about
The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1BResidue 259 is a key determinant of substrate specificity of protein-tyrosine phosphatases 1B and alphaStructure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1BCrystal structure of PTP1B complexed with a potent and selective bidentate inhibitorCrystal structure of the Yersinia protein-tyrosine phosphatase YopH complexed with a specific small molecule inhibitorNew Aspects of the Phosphatase VHZ Revealed by a High-Resolution Structure with Vanadate and Substrate ScreeningStructural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 MutationsDiverse Levels of Sequence Selectivity and Catalytic Efficiency of Protein-Tyrosine PhosphatasesSynergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5The mechanism of allosteric inhibition of protein tyrosine phosphatase 1BSerendipitous discovery of light-induced (In Situ) formation of an Azo-bridged dimeric sulfonated naphthol as a potent PTP1B inhibitor.Structural and evolutionary relationships among protein tyrosine phosphatase domainsOxime-based linker libraries as a general approach for the rapid generation and screening of multidentate inhibitors.Molecular determinants of substrate recognition in hematopoietic protein-tyrosine phosphatase.Bicyclic benzofuran and indole-based salicylic acids as protein tyrosine phosphatase inhibitorsProteomic Analysis of the Excretory and Secretory Proteins of Haemonchus contortus (HcESP) Binding to Goat PBMCs In Vivo Revealed Stage-Specific Binding ProfilesRedox regulation of protein tyrosine phosphatase activity by hydroxyl radical.Molecular mechanism of ERK dephosphorylation by striatal-enriched protein tyrosine phosphatase.Remote hot spots mediate protein substrate recognition for the Cdc25 phosphatase.Thiol-dependent recovery of catalytic activity from oxidized protein tyrosine phosphatases.Covalent inhibition of protein tyrosine phosphatases.Design, synthesis, and evaluation of 2-(arylsulfonyl)oxiranes as cell-permeable covalent inhibitors of protein tyrosine phosphatases.A novel strategy for the development of selective active-site inhibitors of the protein tyrosine phosphatase-like proteins islet-cell antigen 512 (IA-2) and phogrin (IA-2beta).Residue 182 influences the second step of protein-tyrosine phosphatase-mediated catalysis.In vitro enzymatic assays of protein tyrosine phosphatase 1B.The YRD motif is a major determinant of substrate and inhibitor specificity in T-cell protein-tyrosine phosphatase.Classification of binding site conformations of protein tyrosine phosphatase 1B.Probing the molecular basis for potent and selective protein-tyrosine phosphatase 1B inhibition.Novel Mixed-Type Inhibitors of Protein Tyrosine Phosphatase 1B. Kinetic and Computational Studies.Kinetic characterization of the inhibition of protein tyrosine phosphatase-1B by Vanadyl (VO2+) chelates.Regulatory Mechanisms and Novel Therapeutic Targeting Strategies for Protein Tyrosine Phosphatases.Thermodynamic study of ligand binding to protein-tyrosine phosphatase 1B and its substrate-trapping mutants.The Serine/Threonine-Protein Phosphatase 1 From Is Actively Involved in Suppressive Regulatory Roles on Immune Functions of Goat Peripheral Blood Mononuclear Cells
P2860
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P2860
Molecular basis for substrate specificity of protein-tyrosine phosphatase 1B.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Molecular basis for substrate specificity of protein-tyrosine phosphatase 1B.
@en
type
label
Molecular basis for substrate specificity of protein-tyrosine phosphatase 1B.
@en
prefLabel
Molecular basis for substrate specificity of protein-tyrosine phosphatase 1B.
@en
P2093
P2860
P356
P1476
Molecular basis for substrate specificity of protein-tyrosine phosphatase 1B.
@en
P2093
P2860
P304
26368-26374
P356
10.1074/JBC.273.41.26368
P407
P577
1998-10-01T00:00:00Z