The efficient cellular uptake of high density lipoprotein lipids via scavenger receptor class B type I requires not only receptor-mediated surface binding but also receptor-specific lipid transfer mediated by its extracellular domain.
about
Receptor complementation and mutagenesis reveal SR-BI as an essential HCV entry factor and functionally imply its intra- and extra-cellular domainsScavenger receptor class B type I-mediated cholesteryl ester-selective uptake and efflux of unesterified cholesterol. Influence of high density lipoprotein size and structureStructure of LIMP-2 provides functional insights with implications for SR-BI and CD36Identification of a PDZ-domain-containing protein that interacts with the scavenger receptor class B type IACTH Regulation of Adrenal SR-B1Role of advanced glycation end products in cellular signalingMolecular mechanisms of cellular cholesterol effluxHepatitis C Virus entry: the early steps in the viral replication cycleDouble Superhelix Model of High Density LipoproteinRoles of scavenger receptor BI and APO A-I in selective uptake of HDL cholesterol by adrenal cellsIdentification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levelsA carboxyl-terminal PDZ-interacting domain of scavenger receptor B, type I is essential for cell surface expression in liverApoA-II modulates the association of HDL with class B scavenger receptors SR-BI and CD36Uptake of lipoproteins for axonal growth of sympathetic neuronsIn vivo interrogation of the molecular display of atherosclerotic lesion surfaces.Elevated triglyceride content diminishes the capacity of high density lipoprotein to deliver cholesteryl esters via the scavenger receptor class B type I (SR-BI).Dissociation of the high density lipoprotein and low density lipoprotein binding activities of murine scavenger receptor class B type I (mSR-BI) using retrovirus library-based activity dissection.Enhanced hepatic apoA-I secretion and peripheral efflux of cholesterol and phospholipid in CD36 null miceHarnessing high density lipoproteins to block transforming growth factor beta and to inhibit the growth of liver tumor metastases.A novel model of cholesterol efflux from lipid-loaded cellsTryptophan 415 Is Critical for the Cholesterol Transport Functions of Scavenger Receptor BIExtracellular hydrophobic regions in scavenger receptor BI play a key role in mediating HDL-cholesterol transport.Changing concepts of atherogenesis.New developments in selective cholesteryl ester uptake.Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones.High-Density Lipoprotein Proteomics: Identifying New Drug Targets and Biomarkers by Understanding Functionality.Evidence for a Trypanosoma brucei lipoprotein scavenger receptor.Adenosine monophosphate-activated protein kinase induces cholesterol efflux from macrophage-derived foam cells and alleviates atherosclerosis in apolipoprotein E-deficient mice.Scavenger receptor class B type I: a multifunctional receptor.SR-BI/CD36 chimeric receptors define extracellular subdomains of SR-BI critical for cholesterol transport.MicroRNAs 125a and 455 repress lipoprotein-supported steroidogenesis by targeting scavenger receptor class B type I in steroidogenic cells.Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptor SR-BI.Standardizing scavenger receptor nomenclatureFunctional characterization of newly-discovered mutations in human SR-BIAldosterone production in human adrenocortical cells is stimulated by high-density lipoprotein 2 (HDL2) through increased expression of aldosterone synthase (CYP11B2)Negatively cooperative binding of high-density lipoprotein to the HDL receptor SR-BIExpression, purification and reconstitution of the C-terminal transmembrane domain of scavenger receptor BI into detergent micelles for NMR analysis.Glycine dimerization motif in the N-terminal transmembrane domain of the high density lipoprotein receptor SR-BI required for normal receptor oligomerization and lipid transport.Exoplasmic cysteine Cys384 of the HDL receptor SR-BI is critical for its sensitivity to a small-molecule inhibitor and normal lipid transport activityAcrolein impairs the cholesterol transport functions of high density lipoproteins.
P2860
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P2860
The efficient cellular uptake of high density lipoprotein lipids via scavenger receptor class B type I requires not only receptor-mediated surface binding but also receptor-specific lipid transfer mediated by its extracellular domain.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
The efficient cellular uptake ...... d by its extracellular domain.
@en
type
label
The efficient cellular uptake ...... d by its extracellular domain.
@en
prefLabel
The efficient cellular uptake ...... d by its extracellular domain.
@en
P2093
P2860
P356
P1476
The efficient cellular uptake ...... d by its extracellular domain.
@en
P2093
P2860
P304
26338-26348
P356
10.1074/JBC.273.41.26338
P407
P577
1998-10-01T00:00:00Z