Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans.
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Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structuresThe MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formationThe polarity protein Par1b/EMK/MARK2 regulates T cell receptor-induced microtubule-organizing center polarizationThe cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM)An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3Spatio-Temporal Regulation of PKC Isoforms Imparts Signaling SpecificityThe PAR network: redundancy and robustness in a symmetry-breaking systemAsymmetry of early endosome distribution in C. elegans embryosProtein kinase C and extracellular signal-regulated kinase regulate movement, attachment, pairing and egg release in Schistosoma mansoniSmall molecule injection into single-cell C. elegans embryos via carbon-reinforced nanopipettesCDK-1 and two B-type cyclins promote PAR-6 stabilization during polarization of the early C. elegans embryoMemory of cell shape biases stochastic fate decision-making despite mitotic roundingThe Par-3 NTD adopts a PB1-like structure required for Par-3 oligomerization and membrane localizationPolarity and cell fate specification in the control of Caenorhabditis elegans gastrulationInvolvement of Girdin in the determination of cell polarity during cell migrationPhenotypical analysis of atypical PKCs in vivo function display a compensatory system at mouse embryonic day 7.5PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivityPar3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migrationSignaling pathways in cell polarity.The PAR proteins: fundamental players in animal cell polarization.The Par3/aPKC interaction is essential for end bud remodeling and progenitor differentiation during mammary gland morphogenesis.Widely conserved signaling pathways in the establishment of cell polarityStabilization of cell polarity by the C. elegans RING protein PAR-2.aPKC controls microtubule organization to balance adherens junction symmetry and planar polarity during developmentPAR-3 and PAR-1 inhibit LET-99 localization to generate a cortical band important for spindle positioning in Caenorhabditis elegans embryosEvolution of early embryogenesis in rhabditid nematodesPAR-3 mediates the initial clustering and apical localization of junction and polarity proteins during C. elegans intestinal epithelial cell polarizationDifferent domains of C. elegans PAR-3 are required at different times in development.Cell polarity regulator PARD6B is essential for trophectoderm formation in the preimplantation mouse embryo.The C. elegans homolog of Drosophila Lethal giant larvae functions redundantly with PAR-2 to maintain polarity in the early embryo.Interaction of PAR-6 with CDC-42 is required for maintenance but not establishment of PAR asymmetry in C. elegansCoordination of satellite cell activation and self-renewal by Par-complex-dependent asymmetric activation of p38α/β MAPKInfluence of cell polarity on early development of the sea urchin embryoCompartmentalization of the endoplasmic reticulum in the early C. elegans embryos.Identification of the C. elegans anaphase promoting complex subunit Cdc26 by phenotypic profiling and functional rescue in yeast.Spermatid cyst polarization in Drosophila depends upon apkc and the CPEB family translational regulator orb2Binding to PKC-3, but not to PAR-3 or to a conventional PDZ domain ligand, is required for PAR-6 function in C. elegansA genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding.aPKC phosphorylation of Bazooka defines the apical/lateral border in Drosophila epithelial cellsDLG-1 is a MAGUK similar to SAP97 and is required for adherens junction formation.
P2860
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P2860
Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Atypical protein kinase C coop ...... ity in Caenorhabditis elegans.
@en
type
label
Atypical protein kinase C coop ...... ity in Caenorhabditis elegans.
@en
prefLabel
Atypical protein kinase C coop ...... ity in Caenorhabditis elegans.
@en
P2093
P1433
P1476
Atypical protein kinase C coop ...... ity in Caenorhabditis elegans.
@en
P2093
P304
P407
P577
1998-09-01T00:00:00Z