A novel oncogenic mechanism in Ewing sarcoma involving IGF pathway targeting by EWS/Fli1-regulated microRNAs. - Wikidata - wikimedia - TriplyDB

A novel oncogenic mechanism in Ewing sarcoma involving IGF pathway targeting by EWS/Fli1-regulated microRNAs.

A novel oncogenic mechanism in Ewing sarcoma involving IGF pathway targeting by EWS/Fli1-regulated microRNAs.

http://www.wikidata.org/entity/Q38334606

about

Targeting the insulin growth factor receptor 1 Twenty Years on: What Do We Really Know about Ewing Sarcoma and What Is the Path Forward?What Do We Know about the Role of miRNAs in Pediatric Sarcoma?Sequencing Overview of Ewing Sarcoma: A Journey across Genomic, Epigenomic and Transcriptomic Landscapes Molecular mechanisms of ETS transcription factor-mediated tumorigenesis MicroRNAs as potential target in human bone and soft tissue sarcoma therapeutics Ewing sarcoma EWS protein regulates midzone formation by recruiting Aurora B kinase to the midzone Calorie restriction and cancer prevention: a mechanistic perspective.EWS/FLI1 regulates EYA3 in Ewing sarcoma via modulation of miRNA-708, resulting in increased cell survival and chemoresistance.XB130, a new adaptor protein, regulates expression of tumor suppressive microRNAs in cancer cells.Growth-promoting role of the miR-106a~363 cluster in Ewing sarcoma.Differentially expressed miRNAs in Ewing sarcoma compared to mesenchymal stem cells: low miR-31 expression with effects on proliferation and invasion.Epigenetic reprogramming and re-differentiation of a Ewing sarcoma cell line Variable expression of PIK3R3 and PTEN in Ewing Sarcoma impacts oncogenic phenotypes.Ewing sarcoma ewsa protein regulates chondrogenesis of Meckel's cartilage through modulation of Sox9 in zebrafish.The Role of the Insulin/IGF System in Cancer: Lessons Learned from Clinical Trials and the Energy Balance-Cancer Link.Prognostic value of IGF-1R expression in bone and soft tissue sarcomas: a meta-analysis.MiR-193b, downregulated in Ewing Sarcoma, targets the ErbB4 oncogene to inhibit anchorage-independent growth.β-Arrestin-biased agonism as the central mechanism of action for insulin-like growth factor 1 receptor-targeting antibodies in Ewing's sarcoma.Microsatellite instability in sarcoma: fact or fiction?MicroRNAs in Ewing Sarcoma.Modification of the association between obesity and lethal prostate cancer by TMPRSS2:ERG Targeting estrogen-related receptor alpha inhibits epithelial-to-mesenchymal transition and stem cell properties of ovarian cancer cells The roles of microRNAs in sarcomas.MicroRNA-mediated gene regulations in human sarcomas.Friend or foe: the role of microRNA in chemotherapy resistance.The adolescent and young adult with cancer: state of the art -- bone tumors.Good guy or bad guy: the opposing roles of microRNA 125b in cancer Blocking the road, stopping the engine or killing the driver? Advances in targeting EWS/FLI-1 fusion in Ewing sarcoma as novel therapy.The role of miR-17-92 in the miRegulatory landscape of Ewing sarcoma.MicroRNA expression and its clinical implications in Ewing's sarcoma.MiR-30a-5p connects EWS-FLI1 and CD99, two major therapeutic targets in Ewing tumor.MiR-125b inhibits cell biological progression of Ewing's sarcoma by suppressing the PI3K/Akt signalling pathway.The histone demethylase KDM3A is a microRNA-22-regulated tumor promoter in Ewing Sarcoma.Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma.TAF15 is important for cellular proliferation and regulates the expression of a subset of cell cycle genes through miRNAs.Control of MicroRNA-21 expression in colorectal cancer cells by oncogenic epidermal growth factor/Ras signaling and Ets transcription factors.The histone demethylase KDM3A, and its downstream target MCAM, promote Ewing Sarcoma cell migration and metastasis.The Ewing sarcoma secretome and its response to activation of Wnt/beta-catenin signaling.Advances in the Treatment of Pediatric Bone Sarcomas.

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A novel oncogenic mechanism in Ewing sarcoma involving IGF pathway targeting by EWS/Fli1-regulated microRNAs.

http://www.wikidata.org/entity/Q38334606

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B F Niemeyer

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D K Birks

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P2860

MiR-221 and miR-222 target PUMA to induce cell survival in glioblastoma

The inhibition of the highly expressed miR-221 and miR-222 impairs the growth of prostate carcinoma xenografts in mice

The Microprocessor complex mediates the genesis of microRNAs

miR-21 Gene expression triggered by AP-1 is sustained through a double-negative feedback mechanism

MicroRNAs: target recognition and regulatory functions

microRNA-22, downregulated in hepatocellular carcinoma and correlated with prognosis, suppresses cell proliferation and tumourigenicity

Regression of murine lung tumors by the let-7 microRNA

Small silencing RNAs: an expanding universe

Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosis

Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model

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